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IPR006913 is a CENP-V/GFA domain.
<p>Centromere protein (CENP)-V is a kinetochore protein that drives the progression of mitosis by coordinating chromatin condensation, positioning of sister chromatid centromeres and targeting of the chromosome passenger complex (CPC), a machinery that regulates the attachment of spindle microtubules (MTs) to kinetochores. CENP-V homologues are found in all vertebrates as well as in plants and nematodes. At the C-terminal end, CENP-V possesses an evolutionally conserved domain that comprises an array of seven cysteines and shows high structural similarity to glutathione-dependent formaldehyde-activating enzyme (Gfa), an enzyme responsible for formaldehyde detoxification in prokaryotes. CENP-V could be an enzyme that scavenges the formaldehyde produced in histone demethylation reactions. The three central cysteines and the flanking four cysteines separately coordinate to zinc, forming a catalytic centre and a structural fold for a tertiary structure, respectively [[cite:PUB00056760], [cite:PUB00094769], [cite:PUB00032333]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Carbon-sulfur lyase activity | Catalysis of the elimination of hydrogen sulfide or substituted H2S. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: centromere protein V-like [Cicer arietinum] gi|502137544|ref|XP_004503118.1| | 7 | ||
| – | Centromere protein V; TAIR: AT5G16940.1 carbon-sulfur lyase; Swiss-Prot: sp|Q7Z7K6|CENPV_HUMAN Centromere protein V; TrEMBL-Plants: tr|I3SET8|I3SET8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0054800 | 8 | ||
| – | Centromere protein V; TAIR: AT5G16940.1 carbon-sulfur lyase; Swiss-Prot: sp|Q7Z7K6|CENPV_HUMAN Centromere protein V; TrEMBL-Plants: tr|I3SET8|I3SET8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0054800 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF51316 | SUPERFAMILY | 1 | 33.33 |