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IPR011057 is a Mss4-like superfamily.
<p>This superfamily represents a structural domain with a complex fold consisting of several coiled β-sheets. This domain exists as a duplication, consisting of a tandem repeat of two similar structural motifs. These domains can be found in:</p> <ul> <li>Mss4, which contains a zinc-binding site.</li> <li>Translationally controlled tumour-associated protein TCTP, which contains an insertion of an α-helix hairpin, and which lacks a zinc-binding site.</li> <li>The C-terminal MsrB domain of peptide methionine sulphoxide reductase.</li> </ul> <p>Mss4 is a conserved accessory factor for Rab GTPases, which function as ubiquitous regulators of intracellular membrane trafficking [[cite:PUB00014250]]. Mss4 acts to promote nucleotide release from exocytic but not endocytic Rab GTPases. Mss4 has a complex fold made of several coiled β-sheets, and consists of a duplication of tandem repeats of two similar structural motifs. It contains a zinc-binding site.</p> <p>Other proteins that show structure similarity to Mss4 include the translationally controlled tumour-associated proteins TCTPs, which contains an insertion of an α helical hairpin, and lacks the zinc-binding site. TCTPs are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response [[cite:PUB00007168]].</p> <p>The C-terminal MsrB domain of peptide methionine sulphoxide reductase PilB is structurally similar to Mss4. Methionine sulphoxide reductases protect against oxidative damage that can contribute to cell death. The tandem Msr domains (MsrA and MsrB) of the pilB protein from Neisseria gonorrhoeae each reduce different epimeric forms of methionine sulphoxide [[cite:PUB00014251]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Uncharacterized protein TCM_000130 [Theobroma cacao] gi|508698851|gb|EOX90747.1| | 6 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B1, chloroplastic-like [Cicer arietinum] gi|502166101|ref|XP_004513790.1| | 10 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B2, chloroplastic-like [Cicer arietinum] gi|502142277|ref|XP_004504878.1| | 9 | ||
| – | RecName: Full=Translationally-controlled tumor protein homolog; Short=TCTPgi|36963062|gb|AAQ87663.1| translationally controlled tumor protein [Elaeis guineensis] gi|75222628|sp|Q5J907.1|TCTP_ELAGV | 11 | ||
| – | PREDICTED: centromere protein V-like [Cicer arietinum] gi|502137544|ref|XP_004503118.1| | 7 | ||
| – | PREDICTED: peptide methionine sulfoxide reductase B3, chloroplastic-like [Cicer arietinum] gi|502078905|ref|XP_004486092.1| | 9 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT2G17705.1 methionine-S-oxide reductase; Swiss-Prot: sp|Q9STN5|Y4833_ARATH Uncharacterized protein At4g08330, chloroplastic; TrEMBL-Plants: tr|A0A151THX9|A0A151THX9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0377600 | 4 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT1G53670.1 methionine sulfoxide reductase B 1; Swiss-Prot: sp|Q9C8M2|MSRB1_ARATH Peptide methionine sulfoxide reductase B1, chloroplastic; TrEMBL-Plants: tr|I3SVJ6|I3SVJ6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0038500 | 11 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT4G21860.1 methionine sulfoxide reductase B 2; Swiss-Prot: sp|Q9C5C8|MSRB2_ARATH Peptide methionine sulfoxide reductase B2, chloroplastic; TrEMBL-Plants: tr|I3T0F9|I3T0F9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0042500 | 10 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally-controlled tumor protein, putative; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|I3SG51|I3SG51_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0339900 | 14 | ||
| – | Translationally controlled tumor protein; TAIR: AT3G16640.1 translationally controlled tumor protein; Swiss-Prot: sp|Q5J907|TCTP_ELAGV Translationally-controlled tumor protein homolog; TrEMBL-Plants: tr|A0A151U4Q6|A0A151U4Q6_CAJCA Translationally-controlled tumor protein isogeny; Found in the gene: LotjaGi5g1v0224700 | 14 | ||
| – | Centromere protein V; TAIR: AT5G16940.1 carbon-sulfur lyase; Swiss-Prot: sp|Q7Z7K6|CENPV_HUMAN Centromere protein V; TrEMBL-Plants: tr|I3SET8|I3SET8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0054800 | 8 | ||
| – | Centromere protein V; TAIR: AT5G16940.1 carbon-sulfur lyase; Swiss-Prot: sp|Q7Z7K6|CENPV_HUMAN Centromere protein V; TrEMBL-Plants: tr|I3SET8|I3SET8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0054800 | 8 | ||
| – | Peptide methionine sulfoxide reductase msrB; TAIR: AT4G21860.1 methionine sulfoxide reductase B 2; Swiss-Prot: sp|Q10L32|MSRB5_ORYSJ Peptide methionine sulfoxide reductase B5; TrEMBL-Plants: tr|A0A0L9VEM3|A0A0L9VEM3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0302700 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00357 | TIGRFAM | 1 | 6.67 |