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IPR006953

Source: InterPro

Description

IPR006953 is a Vesicle tethering protein Uso1/P115-like, head domain.

<p>This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associated protein (TAP) or Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [[cite:PUB00008680]]. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the Golgi stack. This domain is found in the head region. The head region is highly conserved, but its function is unknown. It does not seem to be essential for vesicle tethering [[cite:PUB00008680]]. The N-terminal part of the head region contains context-detected Armadillo/beta-catenin-like repeats.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000139
Cellular component Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
Subterm of
Part of
GO:0005737
Cellular component Cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Subterm of
GO:0006886
Biological process Intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
Subterm of
Part of
GO:0048280
Biological process Vesicle fusion with Golgi apparatus The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi.
Subterm of
Part of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj2g3v0921550.1
– PREDICTED: golgin candidate 6-like [Cicer arietinum] gi|502090365|ref|XP_004489204.1|
Domains
4
Lj2g3v0921560.2
– PREDICTED: golgin candidate 6-like [Cicer arietinum] gi|502090365|ref|XP_004489204.1|
Domains
12
LotjaGi2g1v0240200.1
– Golgin candidate 6; TAIR: AT3G27530.1 golgin Putative 6; Swiss-Prot: sp|B0F9L4|GOGC6_ARATH Golgin candidate 6; TrEMBL-Plants: tr|A0A151RN78|A0A151RN78_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0240200
Domains
12
LotjaGi2g1v0240200.2
– Golgin candidate 6; TAIR: AT3G27530.1 golgin Putative 6; Swiss-Prot: sp|B0F9L4|GOGC6_ARATH Golgin candidate 6; TrEMBL-Plants: tr|A0A151RN78|A0A151RN78_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0240200
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 25.00