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IPR007015 is a DNA polymerase V/Myb-binding protein 1A.
<p>Proteins of this family are predominantly nucleolar. Myb-binding protein 1A (MYBBP1A) is a transcription regulator that may play an important role in the cellular stress response [[cite:PUB00089664], [cite:PUB00089661], [cite:PUB00089663], [cite:PUB00099537]]. This family also includes the fifth essential DNA polymerase (Pol5p) of Schizosaccharomyces pombe (Fission yeast) and Saccharomyces cerevisiae (Baker's yeast) ([ec:2.7.7.7]). Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units [[cite:PUB00019434]]. This protein was originally thought to be a DNA polymerase, however, later reseach indicated its involvement in ribosome assembly [[cite:PUB00089662], [cite:PUB00099538]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Cellular component | Nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. | ||
| Biological process | Regulation of transcription, DNA-templated | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. | ||
| Molecular function | Transcription factor binding | Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA polymerase V-like isoform 1 [Glycine max] gi|356549489|ref|XP_003543126.1| | 10 | ||
| – | DNA polymerase V; TAIR: AT5G64420.1 DNA polymerase V family; Swiss-Prot: sp|Q7TPV4|MBB1A_MOUSE Myb-binding protein 1A; TrEMBL-Plants: tr|I1M2K6|I1M2K6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0347500 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |