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IPR007148 is a Small-subunit processome, Utp12.
<p>A large ribonuclear protein complex is required for the processing of the small-ribosomal-subunit rRNA -the small-subunit (SSU) processome [[cite:PUB00008496], [cite:PUB00035836]]. This preribosomal complex contains the U3 snoRNA and at least 40 proteins, which have the following properties:</p> <ul> <li>They are nucleolar.</li> <li>They are able to coimmunoprecipitate with the U3 snoRNA and Mpp10 (a protein specific to the SSU processome).</li> <li>They are required for 18S rRNA biogenesis.</li> </ul> <p>There appears to be a linkage between polymerase I transcription and the formation of the SSU processome; as some, but not all, of the SSU processome components are required for pre-rRNA transcription initiation. These SSU processome components have been termed t-Utps. They form a pre-complex with pre-18S rRNA in the absence of snoRNA U3 and other SSU processome components. It has been proposed that the t-Utp complex proteins are both rDNA and rRNA binding proteins that are involved in the initiation of pre18S rRNA transcription. Initially binding to rDNA then associating with the 5' end of the nascent pre18S rRNA. The t-Utpcomplex forms the nucleus around which the rest of the SSU processome components, including snoRNA U3, assemble [[cite:PUB00035837]]. From electron microscopy the SSU processome may correspond to the terminal knobs visualised at the 5' ends of nascent 18S rRNA.</p> <p>This domain is found at the C terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein. In yeast, these proteins are called Utp5, Utp1 or Pwp2, Utp12 or DIP2 [swissprot:Q12220]. They interact with snoRNA U3 and with MPP10 [[cite:PUB00008496]]. Pwp2 is an essential Saccharomyces cerevisiae (Baker's yeast) protein involved in cell separation.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Periodic tryptophan protein-like protein [Medicago truncatula] gi|357507105|ref|XP_003623841.1| | 20 | ||
| – | PREDICTED: WD repeat-containing protein 3-like [Glycine max] gi|356505281|ref|XP_003521420.1| | 21 | ||
| – | Periodic tryptophan protein-like protein [Medicago truncatula] gi|357507105|ref|XP_003623841.1| | 19 | ||
| – | PREDICTED: WD repeat-containing protein 43-like [Glycine max] gi|356522359|ref|XP_003529814.1| | 11 | ||
| – | PREDICTED: WD repeat-containing protein 43-like [Glycine max] gi|356522359|ref|XP_003529814.1| | 3 | ||
| – | PREDICTED: WD repeat-containing protein 43-like [Cicer arietinum] gi|502150903|ref|XP_004508181.1| | 15 | ||
| – | WD40 repeat-like protein; TAIR: AT1G15440.1 periodic tryptophan protein 2; Swiss-Prot: sp|Q15269|PWP2_HUMAN Periodic tryptophan protein 2 homolog; TrEMBL-Plants: tr|A0A0S3RH52|A0A0S3RH52_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0124400 | 21 | ||
| – | WD-repeat protein, putative; TAIR: AT3G21540.1 transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q8BHB4|WDR3_MOUSE WD repeat-containing protein 3; TrEMBL-Plants: tr|K7KFV5|K7KFV5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0685500 | 21 | ||
| – | WD-repeat protein, putative; TAIR: AT3G21540.1 transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q8BHB4|WDR3_MOUSE WD repeat-containing protein 3; TrEMBL-Plants: tr|A0A1J7GXE0|A0A1J7GXE0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0685500 | 21 | ||
| – | WD-repeat protein; TAIR: AT5G11240.1 transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q15061|WDR43_HUMAN WD repeat-containing protein 43; TrEMBL-Plants: tr|K7L3M1|K7L3M1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0337300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 10.00 |