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IPR007269 is a Isoprenylcysteine carboxyl methyltransferase.
<p>The isoprenylcysteine o-methyltransferase ([ec:2.1.1.100]) carries out carboyxl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae, this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology [[cite:PUB00009873]].</p> <p>This entry also includes ICMT from Methanosarcina acetivorans ([swissprot:Q8TMG0]). It comprises a core of five transmembrane α-helices and a cofactor-binding pocket enclosed within a highly conserved C-terminal catalytic subdomain [[cite:PUB00065859]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. | ||
| Biological process | C-terminal protein methylation | The methylation of the C-terminal amino acid of a protein. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein-S-isoprenylcysteine O-methyltransferase A-like isoform X1 [Cicer arietinum] gi|502173037|ref|XP_004515240.1| | 9 | ||
| – | PREDICTED: protein-S-isoprenylcysteine O-methyltransferase B-like [Glycine max] gi|356560077|ref|XP_003548322.1| | 9 | ||
| – | PREDICTED: protein-S-isoprenylcysteine O-methyltransferase B-like [Glycine max] gi|356560077|ref|XP_003548322.1| | 9 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi2g1v0383400 | 11 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi3g1v0239300 | 11 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi5g1v0350300 | 11 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi5g1v0350300 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 14.29 |