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IPR025770 is a Protein-S-isoprenylcysteine O-methyltransferase.
<p>Protein-S-isoprenylcysteine O-methyltransferase catalyses the post-translational methylation of isoprenylated C-terminal cysteine residues [[cite:PUB00057973], [cite:PUB00057974], [cite:PUB00057975], [cite:PUB00057976], [cite:PUB00057977], [cite:PUB00057978], [cite:PUB00057975], [cite:PUB00057976]].</p> <p>Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes present in every life form. They transfer a methyl group most frequently from S-adenosyl L-methionine (SAM or AdoMet) to a nucleophilic acceptor such as oxygen leading to S-adenosyl-L-homocysteine (AdoHcy) and a methylated molecule [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. All these enzymes have in common a conserved region of about 130 amino acid residues that allow them to bind SAM [[cite:PUB00006319]]. The substrates that are methylated by these enzymes cover virtually every kind of biomolecules ranging from small molecules, to lipids, proteins and nucleic acids [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00006319]]. Methyltransferase are therefore involved in many essential cellular processes including biosynthesis, signal transduction, protein repair, chromatin regulation and gene silencing [[cite:PUB00057957], [cite:PUB00057958], [cite:PUB00054125]]. More than 230 families of methyltransferases have been described so far, of which more than 220 use SAM as the methyl donor.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. | ||
| Cellular component | Endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). | ||
| Biological process | C-terminal protein methylation | The methylation of the C-terminal amino acid of a protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein-S-isoprenylcysteine O-methyltransferase A-like isoform X1 [Cicer arietinum] gi|502173037|ref|XP_004515240.1| | 9 | ||
| – | PREDICTED: protein-S-isoprenylcysteine O-methyltransferase B-like [Glycine max] gi|356560077|ref|XP_003548322.1| | 9 | ||
| – | PREDICTED: protein-S-isoprenylcysteine O-methyltransferase B-like [Glycine max] gi|356560077|ref|XP_003548322.1| | 9 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi2g1v0383400 | 11 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi3g1v0239300 | 11 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi5g1v0350300 | 11 | ||
| – | Protein-S-isoprenylcysteine O-methyltransferase; TAIR: AT5G08335.1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Swiss-Prot: sp|Q93W54|ICMTB_ARATH Protein-S-isoprenylcysteine O-methyltransferase B; TrEMBL-Plants: tr|I3S3A6|I3S3A6_LOTJA Protein-S-isoprenylcysteine O-methyltransferase; Found in the gene: LotjaGi5g1v0350300 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 14.29 |