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IPR007325 is a Kynurenine formamidase/cyclase-like.
<p>Kynurenine formamidase catalyses the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation [[cite:PUB00043036]]. The proteins contain a conserved motif HXGTHXDXPXH that is likely to form a part of the active site.</p> <p>This family also includes cyclase-like proteins from plants. They are involved in responses to abiotic stress, and could function as polyketide cyclases [[cite:PUB00088719]]. Isatin hydrolase ([ec:3.5.2.20]), characterized from the bacterium Labrenzia aggregata, is also a member of this family. It is a manganese-binding enzyme that hydrolyses the cyclic amide bond (lactam) of isatin (1H-indole-2,3-dione) to yield isatinate (2-(2-aminophenyl)-2-oxoacetate), during the degradation of the plant hormone indole-3-acetic acid (IAA) [[cite:PUB00090512]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Arylformamidase activity | Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine. | ||
| Biological process | Tryptophan catabolic process to kynurenine | The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: kynurenine formamidase-like [Cicer arietinum] gi|502120433|ref|XP_004496961.1| | 14 | ||
| – | PREDICTED: kynurenine formamidase-like [Cicer arietinum] gi|502120436|ref|XP_004496962.1| | 14 | ||
| – | Kynurenine formamidase; TAIR: AT4G35220.1 Cyclase family protein; Swiss-Prot: sp|Q2N5X0|KYNB_ERYLH Kynurenine formamidase; TrEMBL-Plants: tr|A0A151U7S0|A0A151U7S0_CAJCA Kynurenine formamidase; Found in the gene: LotjaGi5g1v0329100 | 15 | ||
| – | Kynurenine formamidase-like protein; TAIR: AT4G35220.1 Cyclase family protein; Swiss-Prot: sp|Q2S2F5|KYNB_SALRD Kynurenine formamidase; TrEMBL-Plants: tr|I3SIK3|I3SIK3_MEDTR Kynurenine formamidase-like protein; Found in the gene: LotjaGi5g1v0329200 | 14 | ||
| – | Kynurenine formamidase-like protein; TAIR: AT4G35220.1 Cyclase family protein; Swiss-Prot: sp|Q2N5X0|KYNB_ERYLH Kynurenine formamidase; TrEMBL-Plants: tr|I3SIK3|I3SIK3_MEDTR Kynurenine formamidase-like protein; Found in the gene: LotjaGi5g1v0329200 | 14 | ||
| – | Kynurenine formamidase-like protein; TAIR: AT4G35220.1 Cyclase family protein; Swiss-Prot: sp|Q2S2F5|KYNB_SALRD Kynurenine formamidase; TrEMBL-Plants: tr|I3SIK3|I3SIK3_MEDTR Kynurenine formamidase-like protein; Found in the gene: LotjaGi5g1v0329200 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SignalP-noTM | SignalP_GRAM_NEGATIVE | 1 | 16.67 |