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IPR007653 is a Signal peptidase complex subunit 3.
<p>This entry includes signal peptidase complex subunit 3 (Spc3, also known as SPC22) and its homologues from fungi, plants and animals.</p> <p>Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals [[cite:PUB00010061], [cite:PUB00010062]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Signal peptidase complex | A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. | ||
| Biological process | Signal peptide processing | The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. | ||
| Molecular function | Peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: signal peptidase complex subunit 3B-like [Cicer arietinum] gi|502113385|ref|XP_004494633.1| | 12 | ||
| – | PREDICTED: signal peptidase complex subunit 3B-like [Cicer arietinum] gi|502113385|ref|XP_004494633.1| | 12 | ||
| – | PREDICTED: signal peptidase complex subunit 3B-like [Cicer arietinum] gi|502166144|ref|XP_004513803.1| | 3 | ||
| – | Signal peptidase subunit family protein; TAIR: AT3G05230.1 Signal peptidase subunit; Swiss-Prot: sp|Q9MA96|SPC3A_ARATH Signal peptidase complex subunit 3A; TrEMBL-Plants: tr|I3SIR9|I3SIR9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0426600 | 5 | ||
| – | Signal peptidase subunit family protein; TAIR: AT5G27430.1 Signal peptidase subunit; Swiss-Prot: sp|Q53YF3|SPC3B_ARATH Signal peptidase complex subunit 3B; TrEMBL-Plants: tr|I3SIR9|I3SIR9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0774700 | 13 | ||
| – | Signal peptidase subunit; TAIR: AT5G27430.1 Signal peptidase subunit; Swiss-Prot: sp|Q53YF3|SPC3B_ARATH Signal peptidase complex subunit 3B; TrEMBL-Plants: tr|I3S8P8|I3S8P8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0021700 | 13 | ||
| – | Signal peptidase subunit family protein; TAIR: AT3G05230.1 Signal peptidase subunit; Swiss-Prot: sp|Q9MA96|SPC3A_ARATH Signal peptidase complex subunit 3A; TrEMBL-Plants: tr|I3S8P8|I3S8P8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0021700 | 5 | ||
| – | Signal peptidase subunit; TAIR: AT5G27430.1 Signal peptidase subunit; Swiss-Prot: sp|Q53YF3|SPC3B_ARATH Signal peptidase complex subunit 3B; TrEMBL-Plants: tr|I3S8P8|I3S8P8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0021700 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TMhelix | TMHMM | 1 | 12.50 |