Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR007785 is a Anamorsin.
<p>Anamorsin (also named CIAPIN1 for cytokine-induced anti-apoptosis inhibitor 1), is the human homologue of yeast Dre2, a conserved soluble eukaryotic Fe-S cluster protein, that functions in cytosolic Fe-S protein biogenesis [[cite:PUB00064826], [cite:PUB00056284], [cite:PUB00067100], [cite:PUB00059395]]. It is found in both the cytoplasm and in the mitochondrial intermembrane space (IMS) [[cite:PUB00055951]]. Anamorsin is found to be up-regulated in hepatocellular cancer, is considered to be a downstream effector of the receptor tyrosine kinase-Ras signalling pathway, and is essential in mouse definitive haematopoiesis [[cite:PUB00055952]]. In addition, it mediates the anti-apoptotic effects of various cytokines [[cite:PUB00053843]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Cytoplasm | All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. | ||
| Biological process | Iron-sulfur cluster assembly | The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. | ||
| Molecular function | Iron-sulfur cluster binding | Interacting selectively and non-covalently with an iron-sulfur cluster, a combination of iron and sulfur atoms. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: anamorsin homolog [Cicer arietinum] gi|502127212|ref|XP_004499604.1| | 2 | ||
| – | Anamorsin homolog; TAIR: AT5G18400.2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi; Swiss-Prot: sp|B7FNA9|DRE2_MEDTR Anamorsin homolog; TrEMBL-Plants: tr|I3S951|I3S951_LOTJA Anamorsin homolog; Found in the gene: LotjaGi3g1v0526700 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR13273 | PANTHER | 1 | 50.00 |