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IPR007823 is a Ribosomal RNA processing protein 8.
<p>Ribosomal RNA processing protein 8 (Rrp8) is a nucleolar Rossman-fold like methyltransferase. In yeast, it is involved in pre-rRNA cleavage at site A2 [[cite:PUB00078607]] and is responsible for a base methylation of the 25S rRNA [[cite:PUB00078606]]. In humans it is also known as nucleomethylin (NML), and it is important for mediating the assembly of the energy-dependent nucleolar silencing complex (eNoSC), which regulates rRNA transcription in response to glucose deprivation [[cite:PUB00078608]]. NML represses rDNA transcription by promoting H3K9 methylation and establishing heterochromatin across the rDNA [[cite:PUB00050320]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. | ||
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribosomal RNA-processing protein 8-like [Cicer arietinum] gi|502109246|ref|XP_004493600.1| | 5 | ||
| – | PREDICTED: ribosomal RNA-processing protein 8-like [Cicer arietinum] gi|502109246|ref|XP_004493600.1| | 9 | ||
| – | Ribosomal RNA-processing protein 8; TAIR: AT5G40530.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q84JC0|RRP8_ARATH Ribosomal RNA-processing protein 8; TrEMBL-Plants: tr|I3T493|I3T493_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0611800 | 10 | ||
| – | Ribosomal RNA-processing protein 8; TAIR: AT5G40530.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q84JC0|RRP8_ARATH Ribosomal RNA-processing protein 8; TrEMBL-Plants: tr|I3T493|I3T493_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0611800 | 10 | ||
| – | Ribosomal RNA-processing protein 8; TAIR: AT5G40530.4 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q84JC0|RRP8_ARATH Ribosomal RNA-processing protein 8; TrEMBL-Plants: tr|I3T493|I3T493_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0611800 | 10 | ||
| – | Anamorsin homolog; TAIR: AT5G18400.2 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesi; Swiss-Prot: sp|B7FNA9|DRE2_MEDTR Anamorsin homolog; TrEMBL-Plants: tr|I3S951|I3S951_LOTJA Anamorsin homolog; Found in the gene: LotjaGi3g1v0526700 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR13273 | PANTHER | 1 | 16.67 |