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IPR008380 is a HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase.
<p>This family includes a 5'-nucleotidase, [ec:3.1.3.5], specific for purines (IMP and GMP) [[cite:PUB00015569]]. These enzymes are members of the Haloacid Dehalogenase (HAD) superfamily. HAD members are recognised by three short motifs {hhhhDxDx(T/V)}, {hhhh(T/S)}, and either {hhhh(D/E)(D/E)x(3-4)(G/N)} or {hhhh(G/N)(D/E)x(3-4)(D/E)} (where "h" stands for a hydrophobic residue). Crystal structures of many HAD enzymes has verified PSI-PRED predictions of secondary structural elements which show each of the "hhhh" sequences of the motifs as part of β sheets. This subfamily of enzymes is part of "Subfamily I" of the HAD superfamily by virtue of a "cap" domain in between motifs 1 and 2. This subfamily's cap domain has a different predicted secondary structure than all other known HAD enzymes and thus has been designated "subfamily IG", the domain appears to consist of a mixed α/β fold.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: 5'-nucleotidase domain-containing protein DDB_G0275467-like [Cicer arietinum] gi|502150072|ref|XP_004507776.1| | 7 | ||
| – | PREDICTED: 5'-nucleotidase domain-containing protein DDB_G0275467-like [Cicer arietinum] gi|502150072|ref|XP_004507776.1| | 12 | ||
| – | Cytosolic purine 5'-nucleotidase [Medicago truncatula] gi|357479189|ref|XP_003609880.1| | 7 | ||
| – | Cytosolic purine 5'-nucleotidase [Medicago truncatula] gi|357479189|ref|XP_003609880.1| | 7 | ||
| – | PREDICTED: cytosolic purine 5'-nucleotidase-like [Cicer arietinum] gi|502131525|ref|XP_004501012.1| | 12 | ||
| – | Cytosolic purine 5'-nucleotidase; TAIR: AT1G75210.1 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q54XC1|5NTC_DICDI Cytosolic purine 5'-nucleotidase; TrEMBL-Plants: tr|A0A0S3RB16|A0A0S3RB16_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0419300 | 14 | ||
| – | 5' nucleotidase family protein; TAIR: AT2G23890.1 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q75K12|NT5D_DICDI 5'-nucleotidase domain-containing protein DDB_G0275467; TrEMBL-Plants: tr|K7MKA7|K7MKA7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0292500 | 13 | ||
| – | 5' nucleotidase family protein; TAIR: AT2G23890.1 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q75K12|NT5D_DICDI 5'-nucleotidase domain-containing protein DDB_G0275467; TrEMBL-Plants: tr|K7MKA7|K7MKA7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0292500 | 13 | ||
| – | 5' nucleotidase family protein; TAIR: AT2G23890.2 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q75K12|NT5D_DICDI 5'-nucleotidase domain-containing protein DDB_G0275467; TrEMBL-Plants: tr|K7MKA7|K7MKA7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0292500 | 13 | ||
| – | Cytosolic purine 5-nucleotidase; TAIR: AT5G48960.1 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q54XC1|5NTC_DICDI Cytosolic purine 5'-nucleotidase; TrEMBL-Plants: tr|G7JR10|G7JR10_MEDTR Cytosolic purine 5-nucleotidase; Found in the gene: LotjaGi4g1v0314300 | 16 | ||
| – | Cytosolic purine 5'-nucleotidase; TAIR: AT5G48960.1 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q54XC1|5NTC_DICDI Cytosolic purine 5'-nucleotidase; TrEMBL-Plants: tr|A0A151SSF2|A0A151SSF2_CAJCA Cytosolic purine 5'-nucleotidase; Found in the gene: LotjaGi4g1v0314300 | 10 | ||
| – | Cytosolic purine 5-nucleotidase; TAIR: AT5G48960.1 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase; Swiss-Prot: sp|Q54XC1|5NTC_DICDI Cytosolic purine 5'-nucleotidase; TrEMBL-Plants: tr|G7JR10|G7JR10_MEDTR Cytosolic purine 5-nucleotidase; Found in the gene: LotjaGi4g1v0314300 | 12 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07522 | CDD | 1 | 8.33 |