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IPR008989 is a Myosin S1 fragment, N-terminal.
<p>Myosin is a molecular motor that undergoes ATP-driven conformational changes during force production and motility. The S1 fragment myosin head consists of both the globular motor domain, containing the ATP-and actin-binding sites, and the lever arm, which amplifies small conformational changes in the motor domain into larger motions by which myosin moves actin. The motor domain contains four major subdomains linked by three single-stranded joints: the N-terminal subdomain, the upper 50kDa subdomain, the lower 50kDa subdomain, and the C-terminal converter subdomain [[cite:PUB00010710]]. The N-terminal subdomain has an SH3-like partly opened β barrel topology, with the last strand being interrupted by a 3-10 helical turn. The N-terminal and upper 50kDa subdomains together form the nucleotide-binding pocket. The binding of specific nucleotides alters the structural state of the myosin head during the contractile cycle.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Motor activity | Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate. | ||
| Molecular function | ATP binding | Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. | ||
| Molecular function | Actin filament binding | Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Myosin; TAIR: AT1G04600.1 myosin XI A; Swiss-Prot: sp|F4I5Q6|MYO7_ARATH Myosin-7; TrEMBL-Plants: tr|A0A072VH49|A0A072VH49_MEDTR Myosin heavy chain; Found in the gene: LotjaGi2g1v0020800 | 22 | ||
| – | Myosin-related family protein; TAIR: AT3G19960.1 myosin 1; Swiss-Prot: sp|Q9LHE9|MYO1_ARATH Myosin-1; TrEMBL-Plants: tr|I1NCW2|I1NCW2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0024000 | 27 | ||
| – | Myosin-related family protein; TAIR: AT3G19960.1 myosin 1; Swiss-Prot: sp|Q9LHE9|MYO1_ARATH Myosin-1; TrEMBL-Plants: tr|I1NF52|I1NF52_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0353200 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 33.33 |