Description

IPR001609 is a Myosin head, motor domain-like.

<p>Muscle contraction is caused by sliding between the thick and thin filaments of the myofibril. Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains [[cite:PUB00002350]], 2 alkali light chains, and 2 regulatory light chains. The heavy chain can be subdivided into the N-terminal globular head and the C-terminal coiled-coil rod-like tail, although some forms have a globular region in their C-terminal. There are many cell-specific isoforms of myosin heavy chains, coded for by a multi-gene family [[cite:PUB00001579]]. Myosin interacts with actin to convert chemical energy, in the form of ATP, to mechanical energy [[cite:PUB00004629]]. The 3-D structure of the head portion of myosin has been determined [[cite:PUB00005168]] and a model for actin-myosin complex has been constructed [[cite:PUB00005169]].</p> <p>The globular head is well conserved, some highly-conserved regions possibly relating to functional and structural domains [[cite:PUB00004601]]. The rod-like tail starts with an invariant proline residue, and contains many repeats of a 28 residue region, interrupted at 4 regularly-spaced points known as skip residues. Although the sequence of the tail is not well conserved, the chemical character is, hydrophobic, charged and skip residues occuring in a highly ordered and repeated fashion [[cite:PUB00004601]].</p> <p>This domain is also found in chitinases present in filamentous fungi, enzymes that play a critical role in promoting the synthesis of chitin at the hyphal tip, thus influencing fungal growth and the architecture of fungal infection structures [[cite:PUB00155059], [cite:PUB00155058]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 57

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: