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IPR009582 is a Signal peptidase complex subunit 2.
<p>This family represents the Signal peptidase complex subunit 2 (SPCS2) and its homologues, such as Spc2 from budding yeasts. The signal peptidase complex cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER). Mammalian signal peptidase is as a complex of five different polypeptide chains [[cite:PUB00010061]], while the budding yeast SPC comprises four proteins [[cite:PUB00087521]]. Budding yeast Spc2 has been shown to be a nonessential component of the signal peptidase complex [[cite:PUB00094330]]. Spc2 has been shown to enhance the enzymatic activity of the SPC and facilitate the interactions between different components of the translocation site [[cite:PUB00094331]].</p> <p>Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins [[cite:PUB00010061]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Signal peptidase complex | A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. | ||
| Biological process | Signal peptide processing | The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell. | ||
| Molecular function | Peptidase activity | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. | ||
| Cellular component | Integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable signal peptidase complex subunit 2-like [Cicer arietinum] gi|502097270|ref|XP_004490953.1| | 7 | ||
| – | PREDICTED: probable signal peptidase complex subunit 2-like [Cicer arietinum] gi|502097270|ref|XP_004490953.1| | 7 | ||
| – | Signal peptidase subunit-25; TAIR: AT2G39960.1 Microsomal signal peptidase 25 kDa subunit (SPC25); Swiss-Prot: sp|P58684|SPCS2_ARATH Probable signal peptidase complex subunit 2; TrEMBL-Plants: tr|I3T9H9|I3T9H9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0080700 | 8 | ||
| – | Signal peptidase subunit-25; TAIR: AT2G39960.1 Microsomal signal peptidase 25 kDa subunit (SPC25); Swiss-Prot: sp|P58684|SPCS2_ARATH Probable signal peptidase complex subunit 2; TrEMBL-Plants: tr|I3T9H9|I3T9H9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0080900 | 8 | ||
| – | Signal peptidase subunit-25; TAIR: AT2G39960.1 Microsomal signal peptidase 25 kDa subunit (SPC25); Swiss-Prot: sp|P58684|SPCS2_ARATH Probable signal peptidase complex subunit 2; TrEMBL-Plants: tr|I3T9H9|I3T9H9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0080900 | 8 | ||
| – | Signal peptidase subunit-25; TAIR: AT2G39960.1 Microsomal signal peptidase 25 kDa subunit (SPC25); Swiss-Prot: sp|P58684|SPCS2_ARATH Probable signal peptidase complex subunit 2; TrEMBL-Plants: tr|I3T9H9|I3T9H9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0080900 | 8 | ||
| – | Signal peptidase subunit-25; TAIR: AT2G39960.1 Microsomal signal peptidase 25 kDa subunit (SPC25); Swiss-Prot: sp|P58684|SPCS2_ARATH Probable signal peptidase complex subunit 2; TrEMBL-Plants: tr|I3T9H9|I3T9H9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0080900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 14.29 |