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IPR010492 is a GINS complex, subunit Psf3.
<p>DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the pre-replication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origin recognition complex (ORC), Cdc6 and Cdt1 proteins, and the MCM complex. Activation of the pre-RC into the initiation complex (IC) is achieved via the action of S-phase kinases, eventually leading to the loading of the replication machinery.</p> <p>Recently, a novel replication complex, GINS (for Go, Ichi, Nii, and San; five, one, two, and three in Japanese), has been identified [[cite:PUB00012381], [cite:PUB00015004]]. The precise function of GINS is not known. However, genetic and two-hybrid interactions indicate that it mediates the loading of the enzymatic replication machinery at a step after the action of the S-phase kinases [[cite:PUB00015004]]. Furthermore, GINS may be a part of the replication machinery itself, since it is found associated with replicating DNA [[cite:PUB00012381], [cite:PUB00015004]]. Electron microscopy of GINS shows that it forms a ring-like structure [[cite:PUB00012381]], reminiscent of the structure of PCNA [[cite:PUB00015005]], the DNA polymerase delta replication clamp. This observation, coupled with the observed interactions for GINS, indicates that the complex may represent the replication clamp for DNA polymerase epsilon [[cite:PUB00012381]].</p> <p>The GINS complex is essential for initiation of DNA replication in Xenopus egg extracts [[cite:PUB00012381]]. This 100kDa stable complex includes Sld5, Psf1, Psf2, and Psf3. Homologues of these components are found also in other eukaryotes. This family of proteins represents the Psf3 component.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA replication complex GINS protein PSF3-like [Cicer arietinum] gi|502129970|ref|XP_004500486.1| | 7 | ||
| – | DNA replication complex GINS protein PSF3 [Medicago truncatula] gi|357461211|ref|XP_003600887.1| | 4 | ||
| – | DNA replication complex GINS protein PSF3; TAIR: AT1G19080.1 GINS complex protein; Swiss-Prot: sp|Q0UPV4|PSF3_PHANO DNA replication complex GINS protein PSF3; TrEMBL-Plants: tr|A0A1J7H7L2|A0A1J7H7L2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0238400 | 10 | ||
| – | DNA replication complex GINS protein PSF3; TAIR: AT1G19080.1 GINS complex protein; Swiss-Prot: sp|Q0UPV4|PSF3_PHANO DNA replication complex GINS protein PSF3; TrEMBL-Plants: tr|A0A1J7H7L2|A0A1J7H7L2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0238400 | 10 | ||
| – | DNA replication complex GINS protein PSF3; TAIR: AT1G19080.1 GINS complex protein; Swiss-Prot: sp|Q0UPV4|PSF3_PHANO DNA replication complex GINS protein PSF3; TrEMBL-Plants: tr|G7JB86|G7JB86_MEDTR DNA replication complex GINS protein; Found in the gene: LotjaGi6g1v0074400 | 10 | ||
| – | DNA replication complex GINS protein PSF3; TAIR: AT1G19080.1 GINS complex protein; Swiss-Prot: sp|Q0UPV4|PSF3_PHANO DNA replication complex GINS protein PSF3; TrEMBL-Plants: tr|G7JB86|G7JB86_MEDTR DNA replication complex GINS protein; Found in the gene: LotjaGi6g1v0074400 | 10 | ||
| – | DNA replication complex GINS protein PSF3; TAIR: AT1G19080.1 GINS complex protein; Swiss-Prot: sp|Q0UPV4|PSF3_PHANO DNA replication complex GINS protein PSF3; TrEMBL-Plants: tr|A0A1J7H7L2|A0A1J7H7L2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0074400 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11713 | CDD | 1 | 14.29 |