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IPR010970 is a Cysteine desulfurase, SufS.
<p>Cysteine desulfurases are pyridoxal-phosphate enzymes which catalyse the removal of sulphur from L-cysteine to form L-alanine and elemental sulphur. These enzymes have been shown to play an important role in the biosynthesis of iron-sulphur clusters, thionucleosides in tRNA, thiamine, biotin, lipoate and molydopterin [[cite:PUB00028013]].</p> <p>This entry represents a subfamily of NifS-related cysteine desulfurases that are often involved in iron-sulphur cluster formation, which is needed for nitrogen fixation and other vital functions [[cite:PUB00028014]]. Many of these enzymes, in addition to cysteine desulfurase activity, also show selenocysteine lyase activity where L-selenocysteine is converted to L-alanine and selenide [[cite:PUB00028015]]. Some of these enzymes are much more specific for selenocysteine than cysteine and are thus believed to function in selenium metabolism rather than sulphur metabolism.</p> <p>Structural studies of the Escherichia coli [[cite:PUB00026361]] and Synechocystis [[cite:PUB00028016]] enzymes indicate that they are homodimers which show a similar fold to other members of the alpha family of pyridoxal-phosphate enzymes [[cite:PUB00016898]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cysteine metabolic process | The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid. | ||
| Molecular function | Pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. | ||
| Molecular function | Cysteine desulfurase activity | Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cysteine desulfurase 2, chloroplastic-like [Cicer arietinum] gi|502135118|ref|XP_004502227.1| | 15 | ||
| – | Cysteine desulfurase family protein; TAIR: AT1G08490.1 chloroplastic NIFS-like cysteine desulfurase; Swiss-Prot: sp|Q93WX6|CNIF1_ARATH Cysteine desulfurase 1, chloroplastic; TrEMBL-Plants: tr|A0A151REY6|A0A151REY6_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275200 | 15 | ||
| – | Cysteine desulfurase family protein; TAIR: AT1G08490.1 chloroplastic NIFS-like cysteine desulfurase; Swiss-Prot: sp|Q93WX6|CNIF1_ARATH Cysteine desulfurase 1, chloroplastic; TrEMBL-Plants: tr|A0A151REY6|A0A151REY6_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275200 | 15 | ||
| – | Cysteine desulfurase family protein; TAIR: AT1G08490.1 chloroplastic NIFS-like cysteine desulfurase; Swiss-Prot: sp|Q93WX6|CNIF1_ARATH Cysteine desulfurase 1, chloroplastic; TrEMBL-Plants: tr|A0A151REY6|A0A151REY6_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0275200 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06453 | CDD | 1 | 25.00 |