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IPR011320 is a Ribonuclease H1, N-terminal.
<p>This entry represents the N-terminal domain of RNase HI, which has a 3-layer α/β/α structure [[cite:PUB00011751]]. This domain is lacking in retroviral and prokaryotic enzymes, but shows a striking structural similarity to the ribosomal protein L9 N-terminal domain, and may function as a regulatory RNA-binding module. However, the topology of this domain differs from structures of known RNA binding domains such as the double-stranded RNA binding domain (dsRBD), the hnRNP K homology (KH) domain and the RNP motif. Eukaryotic RNases HI possess either one or two copies of this small N-terminal domain, in addition to the well-conserved catalytic RNase H domain. RNase HI belongs to the family of ribonuclease H enzymes that recognise RNA:DNA hybrids and degrade the RNA component.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Hypothetical ribonuclease HI, partial [Vibrio sp]. MED222] gi|497533033|ref|WP_009847231.1| | 5 | ||
| – | RNase H domain-containing protein [Arabidopsis thaliana] gi|334182806|ref|NP_173819.2| | 11 | ||
| – | RNase H domain-containing protein [Arabidopsis thaliana] gi|334182806|ref|NP_173819.2| | 11 | ||
| – | RNase H domain-containing protein [Arabidopsis thaliana] gi|334182806|ref|NP_173819.2| | 11 | ||
| – | Hypothetical ribonuclease HI, partial [Vibrio sp]. MED222] gi|497533033|ref|WP_009847231.1| | 8 | ||
| – | Ribonuclease H [Bacteroidetes oral taxon 274] gi|496508398|ref|WP_009216681.1| | 6 | ||
| – | Hypothetical ribonuclease HI, partial [Vibrio sp]. MED222] gi|497533033|ref|WP_009847231.1| | 5 | ||
| – | Hypothetical ribonuclease HI, partial [Vibrio sp]. MED222] gi|497533033|ref|WP_009847231.1| | 8 | ||
| – | Ribonuclease H [Bacteroidetes oral taxon 274] gi|496508398|ref|WP_009216681.1| | 8 | ||
| – | Chain A, N-Terminal Domain Of Saccharomyces Cerevisiae Rnase Hi Reveals A Fold With A Resemblance To The N-Terminal Domain Of Ribosomal Protein L9] gi|159162900|pdb|1QHK|A | 9 | ||
| – | Ribonuclease H-like protein [Bacillus halodurans C]-125] gi|15613426|ref|NP_241729.1| | 5 | ||
| – | Chain A, N-Terminal Domain Of Saccharomyces Cerevisiae Rnase Hi Reveals A Fold With A Resemblance To The N-Terminal Domain Of Ribosomal Protein L9] gi|159162900|pdb|1QHK|A | 10 | ||
| – | Ribonuclease H; TAIR: AT5G47430.1 DWNN domain, a CCHC-type zinc finger; Swiss-Prot: sp|Q9KEI9|RNH1_BACHD Ribonuclease H; TrEMBL-Plants: tr|A5BTX8|A5BTX8_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0094300_LC | 6 | ||
| – | Ribonuclease H; TAIR: AT2G42900.1 Plant basic secretory protein (BSP) family protein; Swiss-Prot: sp|Q9KEI9|RNH1_BACHD Ribonuclease H; TrEMBL-Plants: tr|A5BTX8|A5BTX8_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0296900_LC | 10 | ||
| – | Transactivator/viroplasmin protein; TAIR: AT5G15540.1 PHD finger family protein; Swiss-Prot: sp|Q9UST8|RNH1_SCHPO Ribonuclease H; TrEMBL-Plants: tr|A5BTX8|A5BTX8_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0687300 | 8 | ||
| – | Transactivator/viroplasmin protein; TAIR: AT5G57450.1 homolog of X-ray repair cross complementing 3 (XRCC3); Swiss-Prot: sp|Q9KEI9|RNH1_BACHD Ribonuclease H; TrEMBL-Plants: tr|A5AV09|A5AV09_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0260600_LC | 10 | ||
| – | Transactivator/viroplasmin protein; TAIR: AT5G51080.3 RNase H family protein; Swiss-Prot: sp|Q9KEI9|RNH1_BACHD Ribonuclease H; TrEMBL-Plants: tr|A0A1B5Z8F4|A0A1B5Z8F4_TRISU Uncharacterized protein; Found in the gene: LotjaGi5g1v0204900 | 7 | ||
| – | Transactivator/viroplasmin protein; TAIR: AT4G30310.3 FGGY family of carbohydrate kinase; Swiss-Prot: sp|Q9KEI9|RNH1_BACHD Ribonuclease H; TrEMBL-Plants: tr|A5BTX8|A5BTX8_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0226600_LC | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 5.56 |