Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

IPR011383

Source: InterPro

Description

IPR011383 is a N-lysine methyltransferase SETD6.

<p>SET domain methyltransferases can be involved both in translational and transcriptional roles. N-lysine methyltransferase SETD6 is a SET domain protein that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity [[cite:PUB00055415]]. Homologues in yeast monomethylate 60S ribosomal protein L42 (RPL42A and RPL42B) at 'Lys-55' [[cite:PUB00042697], [cite:PUB00073597]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016279
Molecular function Protein-lysine N-methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
Subterm of
GO:0018026
Biological process Peptidyl-lysine monomethylation The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj0g3v0132279.2
– PREDICTED: ribosomal N-lysine methyltransferase 3-like [Cicer arietinum] gi|502116507|ref|XP_004495465.1|
Domains
9
LotjaGi5g1v0196700.1
– SET-domain protein lysine methyltransferase family protein; TAIR: AT3G56570.1 SET domain-containing protein; Swiss-Prot: sp|P38222|RKM3_YEAST Ribosomal lysine N-methyltransferase 3; TrEMBL-Plants: tr|V7BDL1|V7BDL1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0196700
Domains
12

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00