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IPR012131 is a Histidinol dehydrogenase.
<p>Histidinol dehydrogenase (HDH) catalyses the terminal step in the biosynthesis of histidine in bacteria, fungi, and plants, the four-electron oxidation of L-histidinol to histidine.</p> <p>In 4-electron dehydrogenases, a single active site catalyses 2 separate oxidation steps: oxidation of the substrate alcohol to an intermediate aldehyde; and oxidation of the aldehyde to the product acid, in this case His [[cite:PUB00000285]]. The reaction proceeds via a tightly- or covalently-bound inter-mediate, and requires the presence of 2 NAD molecules [[cite:PUB00000285]]. By contrast with most dehydrogenases, the substrate is bound before the NAD coenzyme [[cite:PUB00000285]]. A Cys residue has been implicated in the catalytic mechanism of the second oxidative step [[cite:PUB00000285]].</p> <p>In bacteria HDH is a single chain polypeptide; in fungi it is the C-terminal domain of a multifunctional enzyme which catalyses three different steps of histidine biosynthesis; and in plants it is expressed as nuclear encoded protein precursor which is exported to the chloroplast [[cite:PUB00004740]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Histidine biosynthetic process | The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. | ||
| Molecular function | Histidinol dehydrogenase activity | Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+. | ||
| Molecular function | Metal ion binding | Interacting selectively and non-covalently with any metal ion. | ||
| Molecular function | NAD binding | Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: histidinol dehydrogenase, chloroplastic-like [Glycine max] gi|356524921|ref|XP_003531076.1| | 14 | ||
| – | PREDICTED: histidinol dehydrogenase, chloroplastic-like [Glycine max] gi|356555910|ref|XP_003546272.1| | 16 | ||
| – | Histidinol dehydrogenase; TAIR: AT5G63890.1 histidinol dehydrogenase; Swiss-Prot: sp|Q9C5U8|HIS8_ARATH Histidinol dehydrogenase, chloroplastic; TrEMBL-Plants: tr|A0A151S4E7|A0A151S4E7_CAJCA Histidinol dehydrogenase, chloroplastic; Found in the gene: LotjaGi4g1v0026500 | 15 | ||
| – | Histidinol dehydrogenase; TAIR: AT5G63890.1 histidinol dehydrogenase; Swiss-Prot: sp|Q9C5U8|HIS8_ARATH Histidinol dehydrogenase, chloroplastic; TrEMBL-Plants: tr|I3SWQ6|I3SWQ6_LOTJA Histidinol dehydrogenase, chloroplastic; Found in the gene: LotjaGi6g1v0269300 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06572 | CDD | 1 | 25.00 |