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IPR012270

Description

IPR012270 is a CCR4-NOT complex, subunit 3/ 5.

<p>The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1 to Not5), Caf1, Caf40, Caf130 and Ccr4 [[cite:PUB00044101]]. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress [[cite:PUB00044102]]. Caf1 and Ccr4, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1, a putative RNA helicase thought to be a component of the decapping complex [[cite:PUB00010586]]. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [[cite:PUB00044103]].</p> <p>This group represents CCR4-NOT complex, subunits 3 and 5.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
Biological process Regulation of transcription, DNA-templated Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
Cellular component CCR4-NOT core complex The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
CCR4-NOT transcription complex subunit 3; TAIR: AT5G18230.1 transcription regulator NOT2/NOT3/NOT5 family protein; Swiss-Prot: sp|O75175|CNOT3_HUMAN CCR4-NOT transcription complex subunit 3; TrEMBL-Plants: tr|I1ML37|I1ML37_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0640200 13
CCR4-NOT transcription complex subunit 3; TAIR: AT5G18230.1 transcription regulator NOT2/NOT3/NOT5 family protein; Swiss-Prot: sp|O75175|CNOT3_HUMAN CCR4-NOT transcription complex subunit 3; TrEMBL-Plants: tr|I1ML37|I1ML37_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0640200 13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00