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IPR012394 is a Aldehyde dehydrogenase NAD(P)-dependent.
<p>Aldehydes are produced as intermediates during the metabolism of many different compounds including amino acids, carbohydrates, lipids vitamins and steroids [[cite:PUB00033217]]. They are highly reactive compounds whose buildup to excess levels can cause cytotoxic, genotoxic and carcinogenic effects. Aldehyde dehydrogenases oxidise these compounds to their respective carboxylic acids. This is necessary both for the operation of these metabolic pathways, and to prevent the concentration of aldehydes within the cell from reaching toxic levels. Proteins in this entry are NAD(P)-dependent aldehyde dehydrogenases, found in a variety of organisms, including general aldehyde dehydrogensases ([ec:1.2.1.5]), fatty aldehyde dehydrogenases ([ec:1.2.1.3]), and coniferyl aldehyde dehydrogenase ([ec:1.2.1.68]). Structural studies of the Rattus norvegicus protein ([swissprot:P11883]) show that this enzyme is a homodimer where each subunit consists of two α-β-α domains [[cite:PUB00023323]]. The mode of NAD binding differs substantially from that commonly associated with the Rossman fold.</p> <p>Not all enzymes in this family are dehydrogenases. The family also includes beta-apo-4'-carotenal oxygenase from<i>Neurospora crassa</i>which is required for the final step in the synthesis of the carotenoid pigment neurosporaxanthin by oxidising beta-apo-4'-carotenal [[cite:PUB00088404]]; and 4,4'-diapolycopene aldehyde oxidase from<i>Methylomonas</i>which is required for the biosynthesis of a C30 carotenoid dialdehyde pigment [[cite:PUB00088401]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cellular aldehyde metabolic process | The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells. | ||
| Biological process | Oxidation-reduction process | A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: aldehyde dehydrogenase family 3 member F1-like [Glycine max] gi|356557707|ref|XP_003547154.1| | 15 | ||
| – | PREDICTED: aldehyde dehydrogenase family 3 member F1-like [Glycine max] gi|356557707|ref|XP_003547154.1| | 15 | ||
| – | PREDICTED: aldehyde dehydrogenase family 3 member H1-like isoform X1 [Cicer arietinum] gi|502124011|ref|XP_004498346.1| | 14 | ||
| – | PREDICTED: aldehyde dehydrogenase family 3 member H1-like isoform 1 [Glycine max] gi|356552695|ref|XP_003544698.1| | 15 | ||
| – | PREDICTED: aldehyde dehydrogenase family 3 member F1-like [Glycine max] gi|356502944|ref|XP_003520274.1| | 17 | ||
| – | Aldehyde dehydrogenase family 3 member H1 [Medicago truncatula] gi|357463521|ref|XP_003602042.1| | 14 | ||
| – | PREDICTED: aldehyde dehydrogenase 22A1-like [Cicer arietinum] gi|502084770|ref|XP_004487758.1| | 17 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G44170.1 aldehyde dehydrogenase 3H1; Swiss-Prot: sp|Q70DU8|AL3H1_ARATH Aldehyde dehydrogenase family 3 member H1; TrEMBL-Plants: tr|A0A072VFE4|A0A072VFE4_MEDTR Aldehyde dehydrogenase; Found in the gene: LotjaGi1g1v0158200 | 19 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G44170.1 aldehyde dehydrogenase 3H1; Swiss-Prot: sp|Q70DU8|AL3H1_ARATH Aldehyde dehydrogenase family 3 member H1; TrEMBL-Plants: tr|A0A072VGG1|A0A072VGG1_MEDTR Aldehyde dehydrogenase; Found in the gene: LotjaGi1g1v0158200 | 18 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G44170.3 aldehyde dehydrogenase 3H1; Swiss-Prot: sp|Q70DU8|AL3H1_ARATH Aldehyde dehydrogenase family 3 member H1; TrEMBL-Plants: tr|A0A072VGG1|A0A072VGG1_MEDTR Aldehyde dehydrogenase; Found in the gene: LotjaGi1g1v0158200 | 17 | ||
| – | Aldehyde dehydrogenase; TAIR: AT1G44170.1 aldehyde dehydrogenase 3H1; Swiss-Prot: sp|Q70DU8|AL3H1_ARATH Aldehyde dehydrogenase family 3 member H1; TrEMBL-Plants: tr|G7J4Y0|G7J4Y0_MEDTR Aldehyde dehydrogenase; Found in the gene: LotjaGi1g1v0261700 | 14 | ||
| – | Aldehyde dehydrogenase; TAIR: AT4G36250.1 aldehyde dehydrogenase 3F1; Swiss-Prot: sp|Q70E96|AL3F1_ARATH Aldehyde dehydrogenase family 3 member F1; TrEMBL-Plants: tr|A0A0B2RMN2|A0A0B2RMN2_GLYSO Aldehyde dehydrogenase; Found in the gene: LotjaGi3g1v0287200 | 15 | ||
| – | Aldehyde dehydrogenase; TAIR: AT4G36250.1 aldehyde dehydrogenase 3F1; Swiss-Prot: sp|Q70E96|AL3F1_ARATH Aldehyde dehydrogenase family 3 member F1; TrEMBL-Plants: tr|A0A1J7I710|A0A1J7I710_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0493000 | 12 | ||
| – | Aldehyde dehydrogenase; TAIR: AT4G36250.1 aldehyde dehydrogenase 3F1; Swiss-Prot: sp|Q70E96|AL3F1_ARATH Aldehyde dehydrogenase family 3 member F1; TrEMBL-Plants: tr|A0A1J7I710|A0A1J7I710_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0493000 | 12 | ||
| – | Aldehyde dehydrogenase; TAIR: AT4G36250.1 aldehyde dehydrogenase 3F1; Swiss-Prot: sp|Q70E96|AL3F1_ARATH Aldehyde dehydrogenase family 3 member F1; TrEMBL-Plants: tr|A0A1J7I710|A0A1J7I710_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0493000 | 12 | ||
| – | Aldehyde dehydrogenase; TAIR: AT4G36250.1 aldehyde dehydrogenase 3F1; Swiss-Prot: sp|Q70E96|AL3F1_ARATH Aldehyde dehydrogenase family 3 member F1; TrEMBL-Plants: tr|I1JCK5|I1JCK5_SOYBN Aldehyde dehydrogenase; Found in the gene: LotjaGi4g1v0124000 | 12 | ||
| – | Aldehyde dehydrogenase; TAIR: AT4G34240.1 aldehyde dehydrogenase 3I1; Swiss-Prot: sp|Q8W033|AL3I1_ARATH Aldehyde dehydrogenase family 3 member I1, chloroplastic; TrEMBL-Plants: tr|A0A1J7GIQ1|A0A1J7GIQ1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0412600 | 12 | ||
| – | Aldehyde dehydrogenase; TAIR: AT3G66658.2 aldehyde dehydrogenase 22A1; Swiss-Prot: sp|Q0WSF1|AL221_ARATH Aldehyde dehydrogenase 22A1; TrEMBL-Plants: tr|A0A1J7G6D4|A0A1J7G6D4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0258400 | 17 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd07098 | CDD | 1 | 5.56 |