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IPR012462 is a UfSP1/2/DUB, catalytic domain.
<p>This is the C-terminal catalytic domain of human Ufm1-specific protease 2 (UfSP2), Zinc finger-containing ubiquitin peptidase 1 (DUB) and similar eukaryotic proteins. It shows seven α-helices and seven β-strands, resembling the papain-like structure [[cite:PUB00151643]].</p> <p>UfSP1 and UfSP2 are cysteine peptidases required for the processing and activation of Ubiquitin fold modifier 1 (Ufm1, [interpro:IPR005375]) and for its release from conjugated cellular proteins. UfSP1 and UfSP2 are 217 aa and 461 aa respectively [[cite:PUB00034740], [cite:PUB00034739]]. The peptidases belong to MEROPS peptidase family C78, clan CA. The UfSP2 family have an N-terminal extension with one or more zinc finger domains of the C2H2 type, which have been shown to be involved in protein:protein interaction. UfSP2 is present in most, if not all, multi-cellular organisms including plants, nematodes, flies, and mammals, whereas UfSP1 is not present in plants and nematodes [[cite:PUB00034739]].</p> <p>DUB is a deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains [[cite:PUB00152789], [cite:PUB00152787], [cite:PUB00152786]]. It plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage [[cite:PUB00152789], [cite:PUB00152788]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable Ufm1-specific protease-like [Cicer arietinum] gi|502133631|ref|XP_004501836.1| | 5 | ||
| – | PREDICTED: probable Ufm1-specific protease-like [Cicer arietinum] gi|502133631|ref|XP_004501836.1| | 5 | ||
| – | PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like [Cicer arietinum] gi|502095740|ref|XP_004490526.1| | 3 | ||
| – | Zinc finger with UFM1-specific peptidase domain protein; TAIR: AT5G24680.1 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2; Swiss-Prot: sp|Q3SWY8|ZUFSP_BOVIN Zinc finger with UFM1-specific peptidase domain protein; TrEMBL-Plants: tr|K7KA31|K7KA31_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0128500 | 5 | ||
| – | Ufm1-specific protease 2; TAIR: AT3G48380.1 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2; Swiss-Prot: sp|Q9STL8|UFSP_ARATH Probable Ufm1-specific protease; TrEMBL-Plants: tr|V7B0G2|V7B0G2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0230900 | 5 | ||
| – | Zinc finger with UFM1-specific peptidase domain protein; TAIR: AT5G24680.1 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2; Swiss-Prot: sp|Q96AP4|ZUFSP_HUMAN Zinc finger with UFM1-specific peptidase domain protein; TrEMBL-Plants: tr|G7J9Q3|G7J9Q3_MEDTR Zinc finger with UFM1-specific peptidase domain protein; Found in the gene: LotjaGi1g1v0302900 | 6 | ||
| – | Zinc finger with UFM1-specific peptidase domain protein; TAIR: AT5G24680.1 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2; Swiss-Prot: sp|Q96AP4|ZUFSP_HUMAN Zinc finger with UFM1-specific peptidase domain protein; TrEMBL-Plants: tr|G7J9Q3|G7J9Q3_MEDTR Zinc finger with UFM1-specific peptidase domain protein; Found in the gene: LotjaGi1g1v0302900 | 6 | ||
| – | Zinc finger with UFM1-specific peptidase domain protein; TAIR: AT5G24680.1 Peptidase C78, ubiquitin fold modifier-specific peptidase 1/ 2; Swiss-Prot: sp|Q96AP4|ZUFSP_HUMAN Zinc finger with UFM1-specific peptidase domain protein; TrEMBL-Plants: tr|G7J9Q3|G7J9Q3_MEDTR Zinc finger with UFM1-specific peptidase domain protein; Found in the gene: LotjaGi1g1v0302900 | 6 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |