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IPR012466 is a NECAP, PHear domain.
<p>This PH-like domain can be found in the N-terminal region of NECAPs (also known as adaptin ear-binding coat-associated proteins). NECAPs are alpha-ear-binding proteins that enrich on clathrin-coated vesicles (CCVs). NECAP-1 is expressed in brain and non-neuronal tissues and cells while NECAP-2 is ubiquitously expressed. The PH-like domain of NECAPs is a protein-binding interface that mimics the FxDxF motif binding properties of the alpha-ear and is called PHear (PH fold with ear-like function) domain [[cite:PUB00080400]].</p> <p>PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes [[cite:PUB00080401], [cite:PUB00080402], [cite:PUB00080403], [cite:PUB00014130], [cite:PUB00080404]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. | ||
| Cellular component | Membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Non-intrinsic ABC protein 4 [Theobroma cacao] gi|508702515|gb|EOX94411.1| | 9 | ||
| – | PREDICTED: adaptin ear-binding coat-associated protein 2-like [Glycine max] gi|356543898|ref|XP_003540395.1| | 9 | ||
| – | Non-intrinsic ABC protein 4 [Theobroma cacao] gi|508702515|gb|EOX94411.1| | 9 | ||
| – | Non-intrinsic ABC protein 4 [Theobroma cacao] gi|508702515|gb|EOX94411.1| | 9 | ||
| – | Adaptin ear-binding coat-associated protein 1; TAIR: AT3G58600.1 Adaptin ear-binding coat-associated protein 1 NECAP-1; Swiss-Prot: sp|Q5E9Q4|NECP2_BOVIN Adaptin ear-binding coat-associated protein 2; TrEMBL-Plants: tr|I1LUL7|I1LUL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0450100 | 9 | ||
| – | Adaptin ear-binding coat-associated protein 1; TAIR: AT1G03900.1 non-intrinsic ABC protein 4; Swiss-Prot: sp|Q681Q7|Y1390_ARATH Uncharacterized protein At1g03900; TrEMBL-Plants: tr|A0A072VLL1|A0A072VLL1_MEDTR Adaptin ear-binding coat-associated protein 1; Found in the gene: LotjaGi5g1v0157300 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 16.67 |