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IPR012502

Source: InterPro

Description

IPR012502 is a WAPL domain.

<p>The D. melanogaster WAPL protein regulates heterochromatin structure [[cite:PUB00016495]]. It is required to hold sister chromatids of meiotic heterochromatin together and is implicated in both heterochromatin pairing during female meiosis and the modulation of position-effect variegation (PEV). Although the high-sequence conservation is limited to a third of the protein sequence, a WAPL homologue has been identified in mammals. Mammalian WAPL may play a significant role in meiosis as does the Drosophila one. Human WAPL is overexpressed in invasive human cervical cancers and is often associated with cervical carcinogenesis [[cite:PUB00016544], [cite:PUB00043751]].</p> <p>This entry represents a domain found in the WAPL proteins.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj4g3v0450690.1
– WAPL (Wings apart-like protein regulation of heterochromatin) protein [Arabidopsis thaliana] gi|15219850|ref|NP_176298.1|
Domains
9
Lj4g3v0450800.1
– WAPL (Wings apart-like protein regulation of heterochromatin) protein [Arabidopsis thaliana] gi|30682037|ref|NP_172573.2|
Domains
9
LotjaGi4g1v0054000.1
– Wings apart-like protein like; TAIR: AT1G11060.1 WAPL (Wings apart-like protein regulation of heterochromatin) protein; Swiss-Prot: sp|Q7Z5K2|WAPL_HUMAN Wings apart-like protein homolog; TrEMBL-Plants: tr|A0A072UNY9|A0A072UNY9_MEDTR WAPL (Wings apart-like protein regulation of heterochromatin) protein, putative; Found in the gene: LotjaGi4g1v0054000
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33