Description

IPR012718 is a T-complex protein 1, epsilon subunit.

<p>Members of this eukaryotic family are part of the group II chaperonin complex called CCT (chaperonin containing TCP-1 or Tailless Complex Polypeptide 1) or TRiC [[cite:PUB00004127], [cite:PUB00001019]]. Chaperonins are involved in productive folding of proteins [[cite:PUB00080867]]. They share a common general morphology, a double toroid of 2 stacked rings. The archaeal equivalent group II chaperonin is often called the thermosome [[cite:PUB00080871]]. Both the thermosome and the TCP-1 family of proteins are weakly, but significantly [[cite:PUB00004124]], related to the cpn60/groEL chaperonin family (see [interpro:IPR001844]).</p> <p>The TCP-1 protein was first identified in mice where it is especially abundant in testis but present in all cell types. It has since been found and characterised in many other animal species, as well as in yeast, plants and protists. The TCP1 complex has a double-ring structure with central cavities where protein folding takes place [[cite:PUB00074264]]. TCP-1 is a highly conserved protein of about 60kDa (556 to 560 residues) which participates in a hetero-oligomeric 900kDa double-torus shaped particle [[cite:PUB00004129]] with 6 to 8 other different, but homologous, subunits [[cite:PUB00064264]]. These subunits, the chaperonin containing TCP-1 (CCT) subunit beta, gamma, delta, epsilon, zeta and eta are evolutionary related to TCP-1 itself [[cite:PUB00001034], [cite:PUB00005432]]. Non-native proteins are sequestered inside the central cavity and folding is promoted by using energy derived from ATP hydrolysis [[cite:PUB00080868], [cite:PUB00080869], [cite:PUB00080873]]. The CCT is known to act as a molecular chaperone for tubulin, actin and probably some other proteins [[cite:PUB00074265], [cite:PUB00074266]].</p> <p>This family consists exclusively of the CCT epsilon chain (part of a paralogous family) from animals, plants, fungi, and other eukaryotes.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: