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IPR012734

Source: InterPro

Description

IPR012734 is a Dihydroxyacetone kinase.

<p>This family consists of examples of the single chain form of dihydroxyacetone kinase (also called glycerone kinase) that uses ATP ([ec:2.7.1.29]) as the phosphate donor, rather than a phosphoprotein as in Escherichia coli. This form has separable domains homologous to the K and L subunits of the E. coli enzyme, and is found in yeasts and other eukaryotes and in some bacteria, including Citrobacter freundii [[cite:PUB00060926], [cite:PUB00017762]].</p> <p>The member from tomato has been shown to phosphorylate dihydroxyacetone, 3,4-dihydroxy-2-butanone, and some other aldoses and ketoses [[cite:PUB00016695]]. Members from mammals have been shown to catalyse both the phosphorylation of dihydroxyacetone and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate [[cite:PUB00060927]]. In yeast there are two isozymes of dihydroxyacetone kinase (Dak1 and Dak2). They are required for detoxification of dihydroxyacetone (DHA) [[cite:PUB00060928]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004371
Molecular function Glycerone kinase activity Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).
Subterm of
GO:0005524
Molecular function ATP binding Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
Subterm of
GO:0006071
Biological process Glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj2g3v0635680.2
– Dihydroxyacetone kinase family protein [Arabidopsis lyrata subsp]. lyrata] gi|297834694|ref|XP_002885229.1|
Domains
15
LotjaGi2g1v0188200.1
– Dihydroxyacetone kinase family protein; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|I1L410|I1L410_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0188200
Domains
18
LotjaGi2g1v0189200_LC.1
– Dihydroxyacetone kinase family protein; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|I1L410|I1L410_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0189200_LC
Domains
20

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33