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IPR036117 is a DhaL domain superfamily.
<p>Dihydroxyacetone (Dha) kinases are a family of sequence-conserved enzymes that phosphorylate dihydroxyacetone, glyceraldehyde and other short-chain ketoses and aldoses. They can be divided into two groups according to the source of high-energy phosphate that they utilise, either ATP or phosphoenolpyruvate (PEP). The ATP-dependent forms are the two-domain Dha kinases (DAK), which occur in animals, plants and eubacteria. They consist of a Dha binding (K) and an ATP binding (L) domain. The PEP-dependent forms occur only in eubacteria and a few archaebacteria and consist of three subunits. Two subunits, DhaK and DhaL, are homologous to the K and L domains. Intriguingly, the ADP moiety is not exchanged for ATP but remains permanently bound to the DhaL subunit where it is rephosphorylated in situ by the third subunit, DhaM, which is homologous to the IIA domain of the mannose transporter of the bacterial PEP:sugar phosphotransferase system (PTS) [[cite:PUB00039753], [cite:PUB00051102]].</p> <p>The DhaL domain consists of eight antiparallel α-helices arranged in an up-and-down geometry and aligned on a circle. This results in the formation of a helix barrel enclosing a deep pocket. The helices are amphipathic with the hydrophobic side chains directed into the pocket of the barrel and with the polar residues exposed. The nucleotide is bound on the top of the barrel [[cite:PUB00039753], [cite:PUB00017762]].</p> <p>The DhaL α helix barrel fold appears not only as a C-terminal domain in Dha kinases but also as an N-terminal domain in a family of two-domain proteins with unknown function. One representative example is YfhG of Lactococcus lactis [[cite:PUB00017762]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Glycerone kinase activity | Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+). | ||
| Biological process | Glycerol metabolic process | The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Dihydroxyacetone kinase family protein; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|I1L410|I1L410_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0188200 | 18 | ||
| – | Dihydroxyacetone kinase family protein; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|I1L410|I1L410_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0189200_LC | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |