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IPR004006

Source: InterPro

Description

IPR004006 is a DhaK domain.

<p>Dihydroxyacetone (Dha) kinases are a family of sequence-conserved enzymes that phosphorylate dihydroxyacetone, glyceraldehyde and other short-chain ketoses and aldoses. They can be divided into two groups according to the source of high-energy phosphate that they utilise, either ATP or phosphoenolpyruvate (PEP). The ATP-dependent forms are the two-domain Dha kinases (DAK), which occur in animals, plants and eubacteria. They consist of a Dha binding (K) and an ATP binding (L) domain. The PEP-dependent forms occur only in eubacteria and a few archaebacteria and consist of three subunits. Two subunits, DhaK and DhaL, are homologous to the K and L domains. Intriguingly, the ADP moiety is not exchanged for ATP but remains permanently bound to the DhaL subunit where it is rephosphorylated in situ by the third subunit, DhaM, which is homologous to the IIA domain of the mannose transporter of the bacterial PEP:sugar phosphotransferase system (PTS) [[cite:PUB00039753], [cite:PUB00051102]].</p> <p>The DhaK domain consists of two α/β-folds, each containing a six- stranded mixed β-sheet surrounded by six and three helices, respectively. Dha is bound in hemiaminal linkage to the imidazole nitrogen of an invariant histidine [[cite:PUB00017762], [cite:PUB00029449]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004371
Molecular function Glycerone kinase activity Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+).
Subterm of
GO:0006071
Biological process Glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
Subterm of

Associated Lotus transcripts 8

Transcript Name Description Predicted domains Domain count
Lj2g3v0635680.1
– Dihydroxyacetone kinase family protein [Arabidopsis lyrata subsp]. lyrata] gi|297834694|ref|XP_002885229.1|
Domains
17
Lj2g3v0635680.2
– Dihydroxyacetone kinase family protein [Arabidopsis lyrata subsp]. lyrata] gi|297834694|ref|XP_002885229.1|
Domains
15
Lj2g3v0636050.1
– Dihydroxyacetone kinase family protein [Arabidopsis lyrata subsp]. lyrata] gi|297834694|ref|XP_002885229.1|
Domains
16
Lj2g3v0636070.1
– 3,4-dihydroxy-2-butanone kinase [Zea mays] gi|226509698|ref|NP_001148575.1|
Domains
7
LotjaGi2g1v0188200.1
– Dihydroxyacetone kinase family protein; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|I1L410|I1L410_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0188200
Domains
18
LotjaGi2g1v0189200_LC.1
– Dihydroxyacetone kinase family protein; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|I1L410|I1L410_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0189200_LC
Domains
20
LotjaGi3g1v0284900_LC.1
– Dihydroxyacetone kinase family protein; TAIR: AT1G48430.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|K4C8V8|K4C8V8_SOLLC Uncharacterized protein; Found in the gene: LotjaGi3g1v0284900_LC
Domains
9
LotjaGi5g1v0083100_LC.1
– Dihydroxyacetone kinase, putative; TAIR: AT3G17770.1 Dihydroxyacetone kinase; Swiss-Prot: sp|O04059|DHBK_SOLLC Putative 3,4-dihydroxy-2-butanone kinase; TrEMBL-Plants: tr|A0A0B2QTX4|A0A0B2QTX4_GLYSO Putative 3,4-dihydroxy-2-butanone kinase; Found in the gene: LotjaGi5g1v0083100_LC
Domains
8

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 12.50