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IPR012766 is a Alpha,alpha-trehalose-phosphate synthase.
<p>This enzyme catalyzes the key, penultimate step in biosynthesis of trehalose, a compatible solute made as an osmoprotectant in some species in all three domains of life. The gene symbol OtsA stands for osmotically regulated trehalose synthesis A. Trehalose helps protect against both osmotic and thermal stresses, and is made from two glucose subunits. This entry excludes glucosylglycerol-phosphate synthase, an enzyme of an analogous osmoprotectant system in many cyanobacterial strains. This entry does not identify archaeal examples, as they are more divergent than glucosylglycerol-phosphate synthase. Sequences that score in the gray zone between the trusted and noise cut offs include a number of yeast multidomain proteins in which the N-terminal domain may be functionally equivalent to this family. The gray zone also includes the OtsA of Cornyebacterium glutamicum (and related species), shown to be responsible for synthesis of only trace amounts of trehalose while the majority is synthesized by the TreYZ pathway; the significance of OtsA in this species is unclear (see [[cite:PUB00016701]]).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity | Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate. | ||
| Biological process | Trehalose biosynthetic process | The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP]-forming] gi|356554722|ref|XP_003545692.1| | 12 | ||
| – | PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP]-forming] gi|356554722|ref|XP_003545692.1| | 15 | ||
| – | Trehalose-6-phosphate synthase; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|K7MCQ5|K7MCQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039400 | 18 | ||
| – | Trehalose-6-phosphate synthase; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|K7MCQ5|K7MCQ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0039400 | 18 | ||
| – | Trehalose-6-phosphate synthase; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|A0A1J7GDK0|A0A1J7GDK0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0257500 | 23 | ||
| – | Trehalose-6-phosphate synthase; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|A0A1J7GDK0|A0A1J7GDK0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0257500 | 19 | ||
| – | Trehalose-6-phosphate synthase; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|A0A1J7GDK0|A0A1J7GDK0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0303900 | 19 | ||
| – | Trehalose-6-phosphate synthase; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|A0A1J7GDK0|A0A1J7GDK0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0303900 | 23 | ||
| – | Trehalose-6-phosphate synthase, putative; TAIR: AT1G78580.1 trehalose-6-phosphate synthase; Swiss-Prot: sp|Q9SYM4|TPS1_ARATH Alpha,alpha-trehalose-phosphate synthase [UDP]-forming] 1; TrEMBL-Plants: tr|K7KQK7|K7KQK7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0382300 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |