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IPR013024 is a Gamma-glutamyl cyclotransferase-like.
<p>Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is encoded by the gene C7orf24 [[cite:PUB00043815]]. The enzyme participates in the gamma-glutamyl cycle, which plays a pre-eminent role in glutathione homoeostasis [[cite:PUB00080929]]. The synthesis and metabolism of glutathione (L-gamma-glutamyl-L-cysteinylglycine) ties the gamma-glutamyl cycle to numerous cellular processes; glutathione acts as a ubiquitous reducing agent in reductive mechanisms involved in protein and DNA synthesis, transport processes, enzyme activity, and metabolism.</p> <p>AIG2 (avrRpt2-induced gene) is an Arabidopsis protein that exhibits RPS2- and avrRpt2-dependent induction early after infection with Pseudomonas syringae pv maculicola strain ES4326 carrying avrRpt2 [[cite:PUB00040892], [cite:PUB00007984]]. avrRpt2 is an avirulence gene that can convert virulent strains of P. syringae to avirulence on Arabidopsis thaliana, soybean, and bean. This GGCT-like domain is also found in bacterial tellurite-resistance proteins (TrgB) [[cite:PUB00008105]], butirosin biosynthesis protein BtrG [[cite:PUB00035714]], and in proteins described as ChaC, involved in a novel pathway for glutathione degradation [[cite:PUB00080684]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: cation transport regulator-like protein 2-like [Cicer arietinum] gi|502132056|ref|XP_004501211.1| | 7 | ||
| – | AIG2-like protein [Medicago truncatula] gi|357466569|ref|XP_003603569.1| | 9 | ||
| – | Cation transport regulator-like protein [Medicago truncatula] gi|357438635|ref|XP_003589593.1| | 8 | ||
| – | Os03g0854000 [Oryza sativa Japonica Group] gi|115456667|ref|NP_001051934.1| | 8 | ||
| – | AIG2-like (avirulence induced gene) family protein [Theobroma cacao] gi|508718283|gb|EOY10180.1| | 7 | ||
| – | AIG2-like (avirulence induced gene) family protein [Theobroma cacao] gi|508718283|gb|EOY10180.1| | 8 | ||
| – | Uncharacterized protein TCM_021269 [Theobroma cacao] gi|508714700|gb|EOY06597.1| | 4 | ||
| – | Gamma-glutamylcyclotransferase; TAIR: AT1G44790.1 ChaC-like family protein; Swiss-Prot: sp|Q84QC1|GCT23_ARATH Gamma-glutamylcyclotransferase 2-3; TrEMBL-Plants: tr|I3SLS1|I3SLS1_LOTJA Gamma-glutamylcyclotransferase; Found in the gene: LotjaGi1g1v0160600 | 8 | ||
| – | Gamma-glutamylcyclotransferase; TAIR: AT4G31290.1 ChaC-like family protein; Swiss-Prot: sp|Q84MC1|GCT22_ARATH Gamma-glutamylcyclotransferase 2-2; TrEMBL-Plants: tr|I3STL1|I3STL1_LOTJA Gamma-glutamylcyclotransferase; Found in the gene: LotjaGi1g1v0397000 | 9 | ||
| – | Protein AIG2; TAIR: AT2G24390.1 AIG2-like (avirulence induced gene) family protein; Swiss-Prot: sp|A8MRP2|AIGLD_ARATH AIG2-like protein D; TrEMBL-Plants: tr|I3T7E7|I3T7E7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0397300 | 10 | ||
| – | Protein AIG2; TAIR: AT2G24390.1 AIG2-like (avirulence induced gene) family protein; Swiss-Prot: sp|A8MRP2|AIGLD_ARATH AIG2-like protein D; TrEMBL-Plants: tr|I3T7E7|I3T7E7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0397300 | 9 | ||
| – | AIG2-like (Avirulence induced protein) family protein; TAIR: AT5G46720.1 AIG2-like (avirulence induced gene) family protein; Swiss-Prot: sp|Q9M8T3|Y2910_ARATH Putative gamma-glutamylcyclotransferase At3g02910; TrEMBL-Plants: tr|I1J4V3|I1J4V3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0333300 | 10 | ||
| – | AIG2-like (Avirulence induced gene) family protein; TAIR: AT3G02910.1 AIG2-like (avirulence induced gene) family protein; Swiss-Prot: sp|Q9M8T3|Y2910_ARATH Putative gamma-glutamylcyclotransferase At3g02910; TrEMBL-Plants: tr|I1LP52|I1LP52_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0540000 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd06661 | CDD | 1 | 7.69 |