Description

IPR013134 is a RAD50, zinc hook.

<p>The MRN complex (Mre11-Rad50-Nbs1) plays an important role in many DNA metabolic events that involve DNA double-stranded breaks. MRN is one of the first factors to be localised to DNA lesions where it might have a structural role by tethering and stabilising broken chromosomes [[cite:PUB00017209], [cite:PUB00017210], [cite:PUB00101805]].</p> <p>Rad50 is a split ABC-type ATPase; its centre contains a long heptad repeat that folds into an antiparallel coiled coil, bringing the N-terminal (Walker A) and the C-terminal (Walker B) domains in close proximity [[cite:PUB00017211]]. The apex of the coiled coil contains a dimerisation interface, a conserved Cys-X-X-Cys motif in a hook-shaped domain that dimerises with a second hook domain via cysteine-mediated zinc ion coordination. This zinc dependent dimerisation event allows the formation of a complex that has appropriate lengths and conformational properties to link sister chromatids in homologous recombination and DNA ends in non-homologous end-joining.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: