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IPR013627 is a DNA polymerase alpha, subunit B, N-terminal.
<p>This entry represents the N-terminal domain of subunit B of DNA polymerase alpha-primase, an enzyme which is essential for DNA replication in higher eukaryotes as it initiates synthesis on both leading and lagging strand single-stranded DNA templates. It consists of a primase heterodimer that synthesises RNA primers, a DNA polymerase that extends them, and a fourth subunit, p68 (also termed B-subunit), which is believed to regulate the whole complex. This domain docks on the SV40 helicase and activates the viral primosome [[cite:PUB00093651]]. This domain adopts an OB fold [[cite:PUB00052915]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | DNA polymerase alpha subunit B; TAIR: AT1G67630.1 DNA polymerase alpha 2; Swiss-Prot: sp|Q14181|DPOA2_HUMAN DNA polymerase alpha subunit B; TrEMBL-Plants: tr|V7CZZ6|V7CZZ6_PHAVU DNA polymerase alpha subunit B; Found in the gene: LotjaGi6g1v0101100 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 100.00 |