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IPR007185 is a DNA polymerase alpha/delta/epsilon, subunit B.
<p>DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure [[cite:PUB00010584]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). | ||
| Biological process | DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA polymerase alpha subunit B-like isoform X2 [Cicer arietinum] gi|502135414|ref|XP_004502325.1| | 6 | ||
| – | PREDICTED: DNA polymerase alpha subunit B-like isoform X2 [Cicer arietinum] gi|502135414|ref|XP_004502325.1| | 8 | ||
| – | PREDICTED: DNA polymerase delta small subunit-like isoform X1 [Cicer arietinum] gi|502109177|ref|XP_004493584.1| | 6 | ||
| – | PREDICTED: DNA polymerase delta small subunit-like isoform X1 [Cicer arietinum] gi|502109177|ref|XP_004493584.1| | 6 | ||
| – | PREDICTED: DNA polymerase epsilon subunit 2-like [Glycine max] gi|356560075|ref|XP_003548321.1| | 6 | ||
| – | PREDICTED: DNA polymerase alpha subunit B-like [Glycine max] gi|356569195|ref|XP_003552790.1| | 4 | ||
| – | DNA polymerase delta small subunit; TAIR: AT2G42120.2 DNA polymerase delta small subunit; Swiss-Prot: sp|O48520|DPOD2_ARATH DNA polymerase delta small subunit; TrEMBL-Plants: tr|G7KVD6|G7KVD6_MEDTR DNA polymerase delta small subunit; Found in the gene: LotjaGi1g1v0726300 | 10 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 5 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 5 | ||
| – | DNA polymerase epsilon subunit; TAIR: AT5G22110.1 DNA polymerase epsilon subunit B2; Swiss-Prot: sp|Q500V9|DPB2_ARATH DNA polymerase epsilon subunit B; TrEMBL-Plants: tr|A0A0L9VHK9|A0A0L9VHK9_PHAAN DNA polymerase epsilon subunit; Found in the gene: LotjaGi2g1v0185400 | 5 | ||
| – | DNA polymerase alpha subunit B; TAIR: AT1G67630.1 DNA polymerase alpha 2; Swiss-Prot: sp|Q14181|DPOA2_HUMAN DNA polymerase alpha subunit B; TrEMBL-Plants: tr|A0A151U8Z1|A0A151U8Z1_CAJCA DNA polymerase alpha subunit B; Found in the gene: LotjaGi6g1v0024800 | 8 | ||
| – | DNA polymerase alpha subunit B; TAIR: AT1G67630.1 DNA polymerase alpha 2; Swiss-Prot: sp|Q14181|DPOA2_HUMAN DNA polymerase alpha subunit B; TrEMBL-Plants: tr|V7CZZ6|V7CZZ6_PHAVU DNA polymerase alpha subunit B; Found in the gene: LotjaGi6g1v0101100 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 8.33 |