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IPR013915 is a Pre-mRNA-splicing factor 19, coiled-coil region.
<p>This entry represents the coiled-coil region of Prp19.</p> <p>Prp19, also known as DNA repair protein Pso4 (psoralen-sensitive mutant 4), is a ubiquitously expressed multifunctional E3 ubiquitin ligase with pleiotropic activities in DNA damage signalling, repair, and replicative senescence. It functions as a critical component of DNA repair and DNA damage checkpoint complexes. It senses DNA damage, binds double-stranded DNA in a sequence-independent manner, facilitates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phosphorylation and ubiquitination at damaged DNA, and regulates RNA splicing and mitotic spindle formation in its integral capacity as a scaffold for a multimeric core complex [[cite:PUB00137580], [cite:PUB00078520], [cite:PUB00090460], [cite:PUB00039586], [cite:PUB00137582]].</p> <p>Prp19 contains an N-terminal E3 ubiquitin ligase U-box domain with E2 recruitment function that facilitates dimerisation and is essential for its auto-ubiquitination activity in vitro or when overexpressed [[cite:PUB00027592]], a coiled-coil Prp19 homology region that mediates its tetramerisation and interaction with CDC5L and SPF27 [[cite:PUB00137583], [cite:PUB00033314], [cite:PUB00092514]] and a C-terminal seven-bladed WD40 beta-propeller that forms an asymmetrical barrel-shaped structure important for substrate recognition and recruitment [[cite:PUB00155379], [cite:PUB00137581]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: U-box domain-containing protein 72 [Glycine max] gi|356575233|ref|XP_003555746.1| | 22 | ||
– | Transducin/WD40 repeat protein; TAIR: AT2G33340.1 MOS4-associated complex 3B; Swiss-Prot: sp|O22785|PR19B_ARATH Pre-mRNA-processing factor 19 homolog 2; TrEMBL-Plants: tr|I1NEN5|I1NEN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0008600 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd16656 | CDD | 1 | 50.00 |