Description

IPR013915 is a Pre-mRNA-splicing factor 19, coiled-coil region.

<p>This entry represents the coiled-coil region of Prp19.</p> <p>Prp19, also known as DNA repair protein Pso4 (psoralen-sensitive mutant 4), is a ubiquitously expressed multifunctional E3 ubiquitin ligase with pleiotropic activities in DNA damage signalling, repair, and replicative senescence. It functions as a critical component of DNA repair and DNA damage checkpoint complexes. It senses DNA damage, binds double-stranded DNA in a sequence-independent manner, facilitates processing of damaged DNA, promotes DNA end joining, regulates replication protein A (RPA2) phosphorylation and ubiquitination at damaged DNA, and regulates RNA splicing and mitotic spindle formation in its integral capacity as a scaffold for a multimeric core complex [[cite:PUB00137580], [cite:PUB00078520], [cite:PUB00090460], [cite:PUB00039586], [cite:PUB00137582]].</p> <p>Prp19 contains an N-terminal E3 ubiquitin ligase U-box domain with E2 recruitment function that facilitates dimerisation and is essential for its auto-ubiquitination activity in vitro or when overexpressed [[cite:PUB00027592]], a coiled-coil Prp19 homology region that mediates its tetramerisation and interaction with CDC5L and SPF27 [[cite:PUB00137583], [cite:PUB00033314], [cite:PUB00092514]] and a C-terminal seven-bladed WD40 beta-propeller that forms an asymmetrical barrel-shaped structure important for substrate recognition and recruitment [[cite:PUB00155379], [cite:PUB00137581]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: