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IPR038959 is a Pre-mRNA-processing factor 19.
<p>This family includes Pre-mRNA-processing factor 19 (Prp19) and its homologues. Prp19 is an ubiquitin ligase involved in pre-mRNA splicing and the DNA damage response (DDR) [[cite:PUB00078520]]. Human Prp19 is part of the nineteen complex (NTC), which acts as a multimeric E3 ubiquitin ligase in DNA repair and splicing. Prp19 forms a homotetramer and is an autoinhibited E3 ubiquitin ligase; its activation requires its interaction with splicing factors SPF27, CDC5L, and PLRG1 [[cite:PUB00088605]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | MRNA splicing, via spliceosome | The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced. | ||
| Cellular component | Prp19 complex | A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p. | ||
| Biological process | DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. | ||
| Molecular function | Ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transducin/WD40 repeat protein; TAIR: AT2G33340.1 MOS4-associated complex 3B; Swiss-Prot: sp|O22785|PR19B_ARATH Pre-mRNA-processing factor 19 homolog 2; TrEMBL-Plants: tr|I1NEN5|I1NEN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0008600 | 25 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16656 | CDD | 1 | 100.00 |