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IPR013923 is a Autophagy-related protein 16 domain.
<p>Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [[cite:PUB00009839], [cite:PUB00097434]]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate [[cite:PUB00033271]]. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [[cite:PUB00009838]].</p> <p>This entry represents the coiled-coil domain (CC) of autophagy protein 16 (Apg16), which is required for self-assembly. Atg16 is required for the function of the Apg12p-Apg5p conjugate.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: protein tipD-like [Cicer arietinum] gi|502133650|ref|XP_004501842.1| | 18 | ||
| – | PREDICTED: protein tipD-like [Glycine max] gi|356513836|ref|XP_003525614.1| | 20 | ||
| – | WD40 repeat-like protein; TAIR: AT5G50230.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6NNP0|ATG16_ARATH Autophagy-related protein 16; TrEMBL-Plants: tr|V7CBB8|V7CBB8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0230400 | 20 | ||
| – | WD40 repeat-like protein; TAIR: AT5G50230.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6NNP0|ATG16_ARATH Autophagy-related protein 16; TrEMBL-Plants: tr|A0A1J7HIL9|A0A1J7HIL9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0226200 | 22 | ||
| – | WD40 repeat-like protein; TAIR: AT5G50230.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|Q6NNP0|ATG16_ARATH Autophagy-related protein 16; TrEMBL-Plants: tr|A0A1J7HIL9|A0A1J7HIL9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0226200 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00200 | CDD | 1 | 20.00 |