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IPR013956 is a E3 ubiquitin ligase Bre1.
<p>Bre1 is an E3 ubiquitin ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1 in association with the E2 enzyme Rad6/Ubc2 [[cite:PUB00087168]].</p> <p>This entry also includes Bre1 homologues from fission yeasts, Brl1 and Brl2. They are E3 ubiquitin-protein ligase components of the multisubunit protein complex (termed HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1 [[cite:PUB00087169]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. | ||
| Biological process | Histone monoubiquitination | The modification of histones by addition of a single ubiquitin group. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | E3 ubiquitin-protein ligase BRE1-like 2; TAIR: AT1G55250.5 histone mono-ubiquitination 2; Swiss-Prot: sp|Q9C895|BRE1B_ARATH E3 ubiquitin-protein ligase BRE1-like 2; TrEMBL-Plants: tr|A0A0B2SID2|A0A0B2SID2_GLYSO E3 ubiquitin-protein ligase BRE1-like 2; Found in the gene: LotjaGi1g1v0068000 | 15 | ||
| – | E3 ubiquitin-protein ligase BRE1-like 1; TAIR: AT2G44950.1 histone mono-ubiquitination 1; Swiss-Prot: sp|Q8RXD6|BRE1A_ARATH E3 ubiquitin-protein ligase BRE1-like 1; TrEMBL-Plants: tr|K7LQS9|K7LQS9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0599300 | 15 | ||
| – | E3 ubiquitin-protein ligase BRE1-like protein; TAIR: AT2G44950.1 histone mono-ubiquitination 1; Swiss-Prot: sp|Q8RXD6|BRE1A_ARATH E3 ubiquitin-protein ligase BRE1-like 1; TrEMBL-Plants: tr|A0A151R107|A0A151R107_CAJCA E3 ubiquitin-protein ligase BRE1-like 1; Found in the gene: LotjaGi1g1v0599300 | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16499 | CDD | 1 | 33.33 |