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IPR014436

Source: InterPro

Description

IPR014436 is a Extradiol aromatic ring-opening dioxygenase, DODA-type.

<p>4,5-DOPA dioxygenase catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA dioxygenase is a key enzyme in the biosynthetic pathway of the plant pigment betalain [[cite:PUB00027910], [cite:PUB00099570]]. Homologues of DODA are present not only in betalain-producing plants, but also in bacteria and archaea [[cite:PUB00080818]]. This enzyme is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008270
Molecular function Zinc ion binding Interacting selectively and non-covalently with zinc (Zn) ions.
Subterm of
GO:0016701
Molecular function Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor.
Subterm of
GO:0055114
Biological process Oxidation-reduction process A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0318419.1
– PREDICTED: 4,5-DOPA dioxygenase extradiol-like protein-like [Glycine max] gi|356559959|ref|XP_003548263.1|
Domains
9
Lj2g3v0523320.1
–
Domains
11
Lj2g3v0523330.1
– PREDICTED: 4,5-DOPA dioxygenase extradiol-like protein-like [Glycine max] gi|356559959|ref|XP_003548263.1|
Domains
9
Lj2g3v0523450.1
– PREDICTED: 4,5-DOPA dioxygenase extradiol-like protein-like [Glycine max] gi|356559963|ref|XP_003548265.1|
Domains
9
LotjaGi2g1v0166200.1
– 4,5-dioxygenase-like protein; TAIR: AT4G15093.1 catalytic LigB subunit of aromatic ring-opening dioxygenase family; Swiss-Prot: sp|Q70FG7|DODA_BETVU 4,5-DOPA dioxygenase extradiol; TrEMBL-Plants: tr|I3SYT8|I3SYT8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0166200
Domains
9
LotjaGi2g1v0166400.1
– 4,5-dioxygenase-like protein; TAIR: AT4G15093.1 catalytic LigB subunit of aromatic ring-opening dioxygenase family; Swiss-Prot: sp|Q70FG7|DODA_BETVU 4,5-DOPA dioxygenase extradiol; TrEMBL-Plants: tr|I3SFC8|I3SFC8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0166400
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd07363 CDD 1 16.67