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IPR015648 is a Transcription factor DP.
<p>The DP proteins function as binding partners for E2F transcription factors. The association of DP with E2F can either enhances or repress E2F-dependent transcriptional activity.</p> <p>The activities of both DP and E2F proteins are under cell cycle control, being influenced by the level of phosphorylation imparted through the cell cycle regulated activity of cyclin-dependent kinases. Molecules that function to positively regulate the G1/S transition, such as cyclin-cdk complexes, and negatively regulate it, such as the cdk inhibitors, converge on the Rb pathway. A principal role of pRb is in the regulation of the E2F/DP transcription factors, activity of which determines cell-cycle progression [[cite:PUB00035117], [cite:PUB00035118]].</p> <p>Both DP and E2F proteins are endowed with proto-oncogenic activity and, conversely, have been implicated in regulating apoptosis [[cite:PUB00035119]].</p> <p>The DP proteins have been widely evolutionarily conserved and can be found in organisms ranging from Arabidopsis thaliana (Mouse-ear cress) to Homo sapiens (Human).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | DNA-binding transcription factor activity | A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. | ||
| Cellular component | Transcription factor complex | A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. | ||
| Biological process | Regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: transcription factor-like protein DPB-like [Glycine max] gi|356497355|ref|XP_003517526.1| | 13 | ||
| – | PREDICTED: transcription factor-like protein DPB-like [Glycine max] gi|356497355|ref|XP_003517526.1| | 14 | ||
| – | PREDICTED: transcription factor-like protein DPB-like [Cucumis sativus] gi|449438797|ref|XP_004137174.1| | 12 | ||
| – | PREDICTED: transcription factor-like protein DPB-like [Cicer arietinum] gi|502144178|ref|XP_004505605.1| | 7 | ||
| – | Transcription factor; TAIR: AT5G03415.1 Transcription factor DP; Swiss-Prot: sp|Q9FNY2|DPB_ARATH Transcription factor-like protein DPB; TrEMBL-Plants: tr|A0A151SD62|A0A151SD62_CAJCA Transcription factor Dp-1; Found in the gene: LotjaGi1g1v0205000 | 20 | ||
| – | Transcription factor; TAIR: AT5G03415.1 Transcription factor DP; Swiss-Prot: sp|Q9FNY2|DPB_ARATH Transcription factor-like protein DPB; TrEMBL-Plants: tr|A0A151SD62|A0A151SD62_CAJCA Transcription factor Dp-1; Found in the gene: LotjaGi1g1v0205100 | 21 | ||
| – | Transcription factor; TAIR: AT5G03415.1 Transcription factor DP; Swiss-Prot: sp|Q9FNY2|DPB_ARATH Transcription factor-like protein DPB; TrEMBL-Plants: tr|A0A151SD62|A0A151SD62_CAJCA Transcription factor Dp-1; Found in the gene: LotjaGi1g1v0205100 | 21 | ||
| – | Transcription factor; TAIR: AT5G03415.1 Transcription factor DP; Swiss-Prot: sp|Q9FNY2|DPB_ARATH Transcription factor-like protein DPB; TrEMBL-Plants: tr|A0A151SD62|A0A151SD62_CAJCA Transcription factor Dp-1; Found in the gene: LotjaGi4g1v0140500 | 21 | ||
| – | Transcription factor DP; TAIR: AT5G03415.1 Transcription factor DP; Swiss-Prot: sp|Q9FNY2|DPB_ARATH Transcription factor-like protein DPB; TrEMBL-Plants: tr|A0A151SD62|A0A151SD62_CAJCA Transcription factor Dp-1; Found in the gene: LotjaGi4g1v0140500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |