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IPR015844

Source: InterPro

Description

IPR015844 is a Pantothenate kinase, acetyl-CoA regulated, two-domain type.

<p>Pantothenate kinase (PanK, [ec:2.7.1.33]) catalyses the conversion of CAATP and pantothenate to ADP and D-4'-phosphopantothenate, the key regulatory step in the biosynthesis of coenzyme A (CoA) [[cite:PUB00015018]]. Members in this entry represents a two-domain form with an additional C-terminal domain of unknown function. This type of pantothenate kinase is typical for eukaryotes. It is not related by sequence to bacterial PanK ([pirsf:PIRSF000545]) and differs in a number of biochemical properties (such as inhibition by acetyl-CoA) [[cite:PUB00015018], [cite:PUB00015017]]. However, this group also includes proteins from several Gram-positive bacteria ([pirsf:PIRSF036940]) that are suggested to have originated from the eukaryotic form by lateral transfer [[cite:PUB00015017]].</p> <p>Hallervorden-Spatz syndrome is caused by a defect in a pantothenate kinase gene [[cite:PUB00027731]].</p> <p>For additional information please see [[cite:PUB00015016]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0004594
Molecular function Pantothenate kinase activity Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate.
Subterm of
GO:0015937
Biological process Coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0179800.1
– Pantothenate kinase; TAIR: AT4G32180.1 pantothenate kinase 2; Swiss-Prot: sp|Q8L5Y9|PANK2_ARATH Pantothenate kinase 2; TrEMBL-Plants: tr|K7KVS7|K7KVS7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0179800
Domains
19
LotjaGi1g1v0179800.4
– Pantothenate kinase; TAIR: AT4G32180.1 pantothenate kinase 2; Swiss-Prot: sp|Q8L5Y9|PANK2_ARATH Pantothenate kinase 2; TrEMBL-Plants: tr|K7KVS7|K7KVS7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0179800
Domains
18
LotjaGi1g1v0179800.5
– Pantothenate kinase; TAIR: AT4G32180.1 pantothenate kinase 2; Swiss-Prot: sp|Q8L5Y9|PANK2_ARATH Pantothenate kinase 2; TrEMBL-Plants: tr|K7KVS7|K7KVS7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0179800
Domains
18
LotjaGi4g1v0234000.1
– Pantothenate kinase, putative; TAIR: AT4G32180.1 pantothenate kinase 2; Swiss-Prot: sp|Q8L5Y9|PANK2_ARATH Pantothenate kinase 2; TrEMBL-Plants: tr|K7MKQ2|K7MKQ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0234000
Domains
19
LotjaGi4g1v0234000.5
– Pantothenate kinase, putative; TAIR: AT4G32180.1 pantothenate kinase 2; Swiss-Prot: sp|Q8L5Y9|PANK2_ARATH Pantothenate kinase 2; TrEMBL-Plants: tr|I1MTH1|I1MTH1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0234000
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 20.00