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IPR015894

Source: InterPro

Description

IPR015894 is a Guanylate-binding protein, N-terminal.

<p>Guanylate-binding protein is a GTPase that is induced by interferon (IFN)-gamma. GTPases induced by IFN-gamma are key to the protective immunity against microbial and viral pathogens. These GTPases are classified into three groups: the small 47-kd GTPases, the Mx proteins, and the large 65- to 67-kd GTPases. Guanylate-binding proteins (GBP) fall into the last class. In humans, there are seven GBPs (hGBP1-7) [[cite:PUB00035996]]. Structurally, hGBP1 consists of two domains: a compact globular N-terminal domain harbouring the GTPase function, and an α-helical finger-like C-terminal domain ([interpro:IPR003191]). Human GBP1 is secreted from cells without the need of a leader peptide, and has been shown to exhibit antiviral activity against Vesicular stomatitis virus and Encephalomyocarditis virus, as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to IFN-gamma [[cite:PUB00035997]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003924
Molecular function GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Subterm of
GO:0005525
Molecular function GTP binding Interacting selectively and non-covalently with GTP, guanosine triphosphate.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj0g3v0345939.1
– PREDICTED: myosin-2 heavy chain-like [Cicer arietinum] gi|502142765|ref|XP_004505099.1|
Domains
13
Lj4g3v0484810.1
– PREDICTED: myosin-2 heavy chain-like [Cicer arietinum] gi|502142765|ref|XP_004505099.1|
Domains
16
LotjaGi1g1v0714500.1
– Guanylate-binding family protein; TAIR: AT2G38840.1 Guanylate-binding family protein; Swiss-Prot: sp|Q96PP9|GBP4_HUMAN Guanylate-binding protein 4; TrEMBL-Plants: tr|I1L889|I1L889_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0714500
Domains
25
LotjaGi1g1v0714500.2
– Guanylate-binding family protein; TAIR: AT2G38840.1 Guanylate-binding family protein; Swiss-Prot: sp|Q96PP9|GBP4_HUMAN Guanylate-binding protein 4; TrEMBL-Plants: tr|I1L889|I1L889_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0714500
Domains
24
LotjaGi4g1v0062600.1
– Guanylate-binding family protein; TAIR: AT5G46070.1 Guanylate-binding family protein; Swiss-Prot: sp|P32456|GBP2_HUMAN Guanylate-binding protein 2; TrEMBL-Plants: tr|V7CGT1|V7CGT1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0062600
Domains
17
LotjaGi4g1v0062600.2
– Guanylate-binding family protein; TAIR: AT5G46070.1 Guanylate-binding family protein; Swiss-Prot: sp|P32456|GBP2_HUMAN Guanylate-binding protein 2; TrEMBL-Plants: tr|A0A1J7G9U4|A0A1J7G9U4_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0062600
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 16.67