Description

IPR030386 is a GB1/RHD3-type guanine nucleotide-binding (G) domain.

<p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.</p> <p>The GB1/RHD3 GTPase family contains a large G domain (~230 amino acids). It is widespread in eukaryotes, but not detectable in bacteria or archaea. One conserved subfamily is typified by the Arabidopsis protein root hair defective 3 (RHD3), whose othologs are present in all crown group eukaryotes. The other subfamily is typified by the interferon gamma-induced antiviral GB1 protein that is conserved in animals. The other GTPases of this subfamily are the brain finger proteins (BFPs), in which the GTPase domain is combined with an N-terminal RING finger domain, which implicates these proteins in ubiquitin-mediated signaling. Most members of this family have a large C-terminal, α-helical extension that probably participates in protein-protein interactions. The GB1/RHD3-type G domain has a low intrinsic affinity for nucleotide and often depends on nucleotide-dependent homodimerization to facilitate GTP hydrolysis [[cite:PUB00013952], [cite:PUB00019603], [cite:PUB00021560], [cite:PUB00039568], [cite:PUB00072546], [cite:PUB00058994]].</p> <p>The large GB1/RHD3-type G domain consists of a six-stranded β-sheet surrounded by eight helices. It contains the conserved sequence elements of GTP-binding proteins with modifications [[cite:PUB00019603], [cite:PUB00039568], [cite:PUB00058994]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 15

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: