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IPR016020

Source: InterPro

Description

IPR016020 is a Translation initiation factor 3, subunit 12, N-terminal, eukaryotic.

<p>This superfamily represents the N-terminal domain found in several eukaryotic translation initiation factor 3 subunit 12 (eIF-3 p25; also known as subunit K) proteins. Eukaryotic initiation factor 3 (eIF3) is a multi-subunit complex that is required for binding of mRNA to 40S ribosomal subunits, stabilisation of ternary complex binding to 40S subunits, and dissociation of 40S and 60S subunits [[cite:PUB00010248]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003743
Molecular function Translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
Subterm of
GO:0005852
Cellular component Eukaryotic translation initiation factor 3 complex A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs.
Subterm of
GO:0006446
Biological process Regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.
Subterm of
Regulates
GO:0043022
Molecular function Ribosome binding Interacting selectively and non-covalently with any part of a ribosome.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj4g3v2215250.1
– PREDICTED: eukaryotic translation initiation factor 3 subunit K-like [Glycine max] gi|356547978|ref|XP_003542381.1|
Domains
12
LotjaGi4g1v0320000.1
– Eukaryotic translation initiation factor 3 subunit K; TAIR: AT4G33250.1 eukaryotic translation initiation factor 3K; Swiss-Prot: sp|Q94HF1|EIF3K_ORYSJ Eukaryotic translation initiation factor 3 subunit K; TrEMBL-Plants: tr|I3SP58|I3SP58_LOTJA Eukaryotic translation initiation factor 3 subunit K; Found in the gene: LotjaGi4g1v0320000
Domains
16
LotjaGi4g1v0320000.2
– Eukaryotic translation initiation factor 3 subunit K; TAIR: AT4G33250.1 eukaryotic translation initiation factor 3K; Swiss-Prot: sp|Q94HF1|EIF3K_ORYSJ Eukaryotic translation initiation factor 3 subunit K; TrEMBL-Plants: tr|I3SP58|I3SP58_LOTJA Eukaryotic translation initiation factor 3 subunit K; Found in the gene: LotjaGi4g1v0320000
Domains
14

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF48371 SUPERFAMILY 1 33.33