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IPR016528 is a Vacuolar protein sorting-associated protein 11.
<p>This entry includes E3 ubiquitin-protein ligase Pep5 (also known as Vacuolar biogenesis protein END1 and vacuolar protein sorting-associated protein 11, Vps11) from fungi, and its homologues from plants and animals. Pep5 is a peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis [[cite:PUB00073491], [cite:PUB00153717]]. It is also identified as an E3 ubiquitin ligase that regulates histone protein levels in Saccharomyces cerevisiae [[cite:PUB00073489]]. Human Vps11 may play a role in vesicle-mediated protein trafficking [[cite:PUB00073490]].</p> <p>S.cerevisiae END1 mutants described as four vacuolar protein sorting mutants (class C vps) were found to lack a morphologically distinguishable and functional vacuole. These mutants internalise but do not degrade alpha-factor [[cite:PUB00154369]]. They were also partly defective for mating. These response defects of END1 mutants were attributed to partial defects in signal transduction [[cite:PUB00154369]]. The effects of these mutant defects were linked to the importance of a functional vacuole for optimal response to pheromone.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Glycine max] gi|356520730|ref|XP_003529013.1| | 7 | ||
| – | PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Cicer arietinum] gi|502181646|ref|XP_004516854.1| | 21 | ||
| – | PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Glycine max] gi|356520730|ref|XP_003529013.1| | 5 | ||
| – | Vacuolar protein sorting-associated protein 11 like; TAIR: AT2G05170.1 vacuolar protein sorting 11; Swiss-Prot: sp|Q9SJ40|VPS11_ARATH Vacuolar protein-sorting-associated protein 11 homolog; TrEMBL-Plants: tr|I1KJF2|I1KJF2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0555100 | 20 | ||
| – | Vacuolar protein sorting-associated protein 11 like; TAIR: AT2G05170.1 vacuolar protein sorting 11; Swiss-Prot: sp|Q9SJ40|VPS11_ARATH Vacuolar protein-sorting-associated protein 11 homolog; TrEMBL-Plants: tr|I1KJF2|I1KJF2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0555100 | 20 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16688 | CDD | 1 | 20.00 |