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IPR016555 is a Phospholipase D, eukaryotic type.
<p>This entry includes the lipid-signaling enzymes phospholipase D1 (PLD1) and D2 (PLD2) [[cite:PUB00073523]]. They have roles in immune cell migration [[cite:PUB00073524], [cite:PUB00073527]] and phagocytosis [[cite:PUB00073525], [cite:PUB00073526]]. PLD1 is selectively required during extravasation of macrophages from the bloodstream to sites of damage [[cite:PUB00073528]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phospholipase D activity | Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate. | ||
| Biological process | Phosphatidic acid biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. | ||
| Biological process | Inositol lipid-mediated signaling | A series of molecular signals in which a cell uses an inositol-containing lipid to convert a signal into a response. Inositol lipids include the phosphoinositides (phosphatidylinositol and its phosphorylated derivatives), ceramides containing inositol, and inositol glycolipids. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phospholipase D; TAIR: AT3G16785.1 phospholipase D P1; Swiss-Prot: sp|Q9LRZ5|PLDZ1_ARATH Phospholipase D zeta 1; TrEMBL-Plants: tr|V7BGF2|V7BGF2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0226900 | 23 | ||
| – | Phospholipase D; TAIR: AT3G16785.1 phospholipase D P1; Swiss-Prot: sp|Q9LRZ5|PLDZ1_ARATH Phospholipase D zeta 1; TrEMBL-Plants: tr|I1MGP5|I1MGP5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0252900 | 22 | ||
| – | Phospholipase D; TAIR: AT3G16785.1 phospholipase D P1; Swiss-Prot: sp|Q9LRZ5|PLDZ1_ARATH Phospholipase D zeta 1; TrEMBL-Plants: tr|A0A0B2QY87|A0A0B2QY87_GLYSO Phospholipase D p1; Found in the gene: LotjaGi6g1v0252900 | 22 | ||
| – | Phospholipase D; TAIR: AT3G16785.1 phospholipase D P1; Swiss-Prot: sp|Q9LRZ5|PLDZ1_ARATH Phospholipase D zeta 1; TrEMBL-Plants: tr|A0A0B2QY87|A0A0B2QY87_GLYSO Phospholipase D p1; Found in the gene: LotjaGi6g1v0252900 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |