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IPR016818 is a Nitric oxide synthase-interacting protein.
<p>This entry includes animal NOSIP (nitric oxide synthase-interacting protein) and plant CSU1. They are ubiquitin E3 ligases [[cite:PUB00086890], [cite:PUB00086891]]. Human NOSIP negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity [[cite:PUB00073598], [cite:PUB00073599], [cite:PUB00073600]].</p> <p>Arabidopsis CSU1 plays a important role in maintaining COP1 homeostasis by targeting COP1 for ubiquitination and degradation in dark-grown seedlings [[cite:PUB00086891]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: nitric oxide synthase-interacting protein-like [Cicer arietinum] gi|502077568|ref|XP_004485689.1| | 17 | ||
| – | Nitric oxide synthase-interacting protein homolog; TAIR: AT1G61620.1 phosphoinositide binding protein; Swiss-Prot: sp|Q6NUH3|NOSIP_XENLA Nitric oxide synthase-interacting protein; TrEMBL-Plants: tr|I3SS86|I3SS86_LOTJA Nitric oxide synthase-interacting protein homolog; Found in the gene: LotjaGi6g1v0341700 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd16513 | CDD | 1 | 50.00 |