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GO:0061630

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Ubiquitin protein ligase activity
Full defintion Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
Subterm of

Relationships

The relationship of GO:0061630 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCtb
PMID
The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK
EMBO J. 2012 Oct 3; 31 (19): 3833–44.PMID: 22863777

Activation of the NF-κB pathway requires the formation of Met1-linked 'linear' ubiquitin chains on NEMO, which is catalysed by the Linear Ubiquitin Chain Assembly Complex (LUBAC) E3 consisting of HOIP, HOIL-1L and Sharpin. Here, we show that both LUBAC catalytic activity and LUBAC specificity for linear ubiquitin chain formation are embedded within the RING-IBR-RING (RBR) ubiquitin ligase subunit HOIP. Linear ubiquitin chain formation by HOIP proceeds via a two-step mechanism involving both RING and HECT E3-type activities. RING1-IBR catalyses the transfer of ubiquitin from the E2 onto RING2, to transiently form a HECT-like covalent thioester intermediate. Next, the ubiquitin is transferred from HOIP onto the N-terminus of a target ubiquitin. This transfer is facilitated by a unique region in the C-terminus of HOIP that we termed 'Linear ubiquitin chain Determining Domain' (LDD), which may coordinate the acceptor ubiquitin. Consistent with this mechanism, the RING2-LDD region was found to be important for NF-κB activation in cellular assays. These data show how HOIP combines a general RBR ubiquitin ligase mechanism with unique, LDD-dependent specificity for producing linear ubiquitin chains.

Associated Lotus transcripts 28

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj1g3v0129510.1
– PREDICTED: E3 ubiquitin-protein ligase synoviolin-like [Glycine max] gi|356538686|ref|XP_003537832.1|
GO terms
4
Lj1g3v3716430.1
–
GO terms
4
Lj6g3v0933510.1
– E3 ubiquitin-protein ligase synoviolin [Medicago truncatula] gi|357481129|ref|XP_003610850.1|
GO terms
4
Lj6g3v2116880.1
– PREDICTED: nitric oxide synthase-interacting protein-like [Cicer arietinum] gi|502077568|ref|XP_004485689.1|
GO terms
1
LotjaGi1g1v0053500.1
– RING/U-box superfamily protein; TAIR: AT2G40830.1 RING-H2 finger C1A; Swiss-Prot: sp|O22197|RHC1A_ARATH Probable E3 ubiquitin-protein ligase RHC1A; TrEMBL-Plants: tr|A0A151QZ96|A0A151QZ96_CAJCA RING finger protein 126 family; Found in the gene: LotjaGi1g1v0053500
GO terms
1
LotjaGi1g1v0053500.2
– RING/U-box superfamily protein; TAIR: AT2G40830.1 RING-H2 finger C1A; Swiss-Prot: sp|O22197|RHC1A_ARATH Probable E3 ubiquitin-protein ligase RHC1A; TrEMBL-Plants: tr|A0A151QZ96|A0A151QZ96_CAJCA RING finger protein 126 family; Found in the gene: LotjaGi1g1v0053500
GO terms
1
LotjaGi1g1v0067500.1
– E3 ubiquitin-protein ligase COP1; TAIR: AT2G32950.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|P93471|COP1_PEA E3 ubiquitin-protein ligase COP1; TrEMBL-Plants: tr|G7KH91|G7KH91_MEDTR E3 ubiquitin-protein ligase COP1; Found in the gene: LotjaGi1g1v0067500
GO terms
1
LotjaGi1g1v0088400.1
– RING/U-box superfamily protein; TAIR: AT5G59550.2 zinc finger (C3HC4-type RING finger) family protein; Swiss-Prot: sp|Q940T5|RDUF2_ARATH E3 ubiquitin-protein ligase RDUF2; TrEMBL-Plants: tr|I1JI05|I1JI05_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0088400
GO terms
1
LotjaGi1g1v0111300.1
– E3 ubiquitin-protein ligase listerin-like protein; TAIR: AT5G58410.2 HEAT/U-box domain-containing protein; Swiss-Prot: sp|Q9FGI1|LTN1_ARATH E3 ubiquitin-protein ligase listerin; TrEMBL-Plants: tr|K7KAA3|K7KAA3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0111300
GO terms
3
LotjaGi1g1v0111300.2
– E3 ubiquitin-protein ligase listerin-like protein; TAIR: AT5G58410.2 HEAT/U-box domain-containing protein; Swiss-Prot: sp|Q9FGI1|LTN1_ARATH E3 ubiquitin-protein ligase listerin; TrEMBL-Plants: tr|K7KAA3|K7KAA3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0111300
GO terms
3
LotjaGi1g1v0257800.1
– RING/U-box superfamily protein, putative; TAIR: AT1G60360.1 RING/U-box superfamily protein; Swiss-Prot: sp|P0CH30|RING1_GOSHI E3 ubiquitin-protein ligase RING1; TrEMBL-Plants: tr|A0A1J7HBW1|A0A1J7HBW1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0257800
GO terms
1
LotjaGi1g1v0406000.1
– RING/U-box superfamily protein; TAIR: AT5G11620.1 SWIM zinc finger family protein / mitogen-activated protein kinase kinase kinase (MAPKKK)-like protein; Swiss-Prot: sp|Q62925|M3K1_RAT Mitogen-activated protein kinase kinase kinase 1; TrEMBL-Plants: tr|G7J3G2|G7J3G2_MEDTR SWIM zinc finger protein/MAP kinase kinase kinase (Mapkkk), putative; Found in the gene: LotjaGi1g1v0406000
GO terms
1
LotjaGi1g1v0580400.1
– E3 ubiquitin-protein ligase; TAIR: AT5G02310.1 proteolysis 6; Swiss-Prot: sp|F4KCC2|PRT6_ARATH E3 ubiquitin-protein ligase PRT6; TrEMBL-Plants: tr|I1KJZ0|I1KJZ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0580400
GO terms
2
LotjaGi2g1v0180200.1
– RING/U-box superfamily protein; TAIR: AT3G19950.2 RING/U-box superfamily protein; Swiss-Prot: sp|P0CH30|RING1_GOSHI E3 ubiquitin-protein ligase RING1; TrEMBL-Plants: tr|A0A0L9VIQ9|A0A0L9VIQ9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0180200
GO terms
1
LotjaGi2g1v0207100.1
– E3 ubiquitin-protein ligase RING1; TAIR: AT3G19950.2 RING/U-box superfamily protein; Swiss-Prot: sp|Q8LPN7|RNG1L_ARATH E3 ubiquitin-protein ligase RING1-like; TrEMBL-Plants: tr|A0A151TWL1|A0A151TWL1_CAJCA E3 ubiquitin-protein ligase rnf181 family; Found in the gene: LotjaGi2g1v0207100
GO terms
1
LotjaGi2g1v0441800.1
– PHD finger family protein; TAIR: AT4G23860.1 PHD finger protein-like protein; Swiss-Prot: sp|Q8N806|UBR7_HUMAN Putative E3 ubiquitin-protein ligase UBR7; TrEMBL-Plants: tr|I1JAE1|I1JAE1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0441800
GO terms
2
LotjaGi3g1v0067500_LC.1
– E3 ubiquitin-protein ligase; TAIR: AT3G60300.1 RWD domain-containing protein; Swiss-Prot: sp|Q9QZR0|RNF25_MOUSE E3 ubiquitin-protein ligase RNF25; TrEMBL-Plants: tr|A0A072TK21|A0A072TK21_MEDTR RING finger protein; Found in the gene: LotjaGi3g1v0067500_LC
GO terms
1
LotjaGi3g1v0128300_LC.1
– RING/U-box superfamily protein; TAIR: AT3G60080.1 RING/U-box superfamily protein; Swiss-Prot: sp|Q9SPL2|CIP8_ARATH E3 ubiquitin-protein ligase CIP8; TrEMBL-Plants: tr|V7BVQ9|V7BVQ9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0128300_LC
GO terms
1
LotjaGi3g1v0128300_LC.2
– RING/U-box superfamily protein; TAIR: AT3G60080.1 RING/U-box superfamily protein; Swiss-Prot: sp|Q9SPL2|CIP8_ARATH E3 ubiquitin-protein ligase CIP8; TrEMBL-Plants: tr|V7BVQ9|V7BVQ9_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0128300_LC
GO terms
1
LotjaGi3g1v0202800.1
– E3 ubiquitin-protein ligase Hakai; TAIR: AT5G01160.1 RING/U-box superfamily protein; Swiss-Prot: sp|Q5ZHZ4|HAKAI_CHICK E3 ubiquitin-protein ligase Hakai; TrEMBL-Plants: tr|I1N2T3|I1N2T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0202800
GO terms
2
LotjaGi3g1v0285400.1
– RING/U-box superfamily protein; TAIR: AT3G46620.1 zinc finger (C3HC4-type RING finger) family protein; Swiss-Prot: sp|Q9SNB6|RDUF1_ARATH E3 ubiquitin-protein ligase RDUF1; TrEMBL-Plants: tr|Q2HS43|Q2HS43_MEDTR Zinc finger, C3HC4 type (RING finger) protein, putative; Found in the gene: LotjaGi3g1v0285400
GO terms
1
LotjaGi4g1v0201400.1
– DWNN domain, A CCHC-type zinc finger protein; TAIR: AT5G47430.1 DWNN domain, a CCHC-type zinc finger; Swiss-Prot: sp|B9DFV2|PQT3L_ARATH E3 ubiquitin ligase PQT3-like; TrEMBL-Plants: tr|A0A151SKU9|A0A151SKU9_CAJCA Retinoblastoma-binding protein 6; Found in the gene: LotjaGi4g1v0201400
GO terms
3
LotjaGi5g1v0132600.1
– RING/U-box superfamily protein; TAIR: AT2G40830.1 RING-H2 finger C1A; Swiss-Prot: sp|O22197|RHC1A_ARATH Probable E3 ubiquitin-protein ligase RHC1A; TrEMBL-Plants: tr|I3SUR7|I3SUR7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0132600
GO terms
1
LotjaGi5g1v0353500.1
– RING/U-box superfamily protein; TAIR: AT5G64920.1 COP1-interacting protein 8; Swiss-Prot: sp|Q9SPL2|CIP8_ARATH E3 ubiquitin-protein ligase CIP8; TrEMBL-Plants: tr|V7BE55|V7BE55_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0353500
GO terms
1
LotjaGi6g1v0008600.1
– Transducin/WD40 repeat protein; TAIR: AT2G33340.1 MOS4-associated complex 3B; Swiss-Prot: sp|O22785|PR19B_ARATH Pre-mRNA-processing factor 19 homolog 2; TrEMBL-Plants: tr|I1NEN5|I1NEN5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0008600
GO terms
4
LotjaGi6g1v0031300.1
– RING/U-box superfamily protein; TAIR: AT5G56340.1 RING/U-box superfamily protein; Swiss-Prot: sp|P0CH30|RING1_GOSHI E3 ubiquitin-protein ligase RING1; TrEMBL-Plants: tr|A0A151U8J5|A0A151U8J5_CAJCA RING finger protein 115; Found in the gene: LotjaGi6g1v0031300
GO terms
1
LotjaGi6g1v0063000.1
– RING/U-box superfamily protein; TAIR: AT2G39720.1 RING-H2 finger C2A; Swiss-Prot: sp|O22283|RHC2A_ARATH Probable E3 ubiquitin-protein ligase RHC2A; TrEMBL-Plants: tr|V7CZ69|V7CZ69_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0063000
GO terms
1
LotjaGi6g1v0341700.1
– Nitric oxide synthase-interacting protein homolog; TAIR: AT1G61620.1 phosphoinositide binding protein; Swiss-Prot: sp|Q6NUH3|NOSIP_XENLA Nitric oxide synthase-interacting protein; TrEMBL-Plants: tr|I3SS86|I3SS86_LOTJA Nitric oxide synthase-interacting protein homolog; Found in the gene: LotjaGi6g1v0341700
GO terms
1

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0061630
Molecular function Ubiquitin protein ligase activity 1 3.57