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IPR016819 is a Ribonuclease P/MRP protein subunit Pop5.
<p>Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [[cite:PUB00006321]]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) [[cite:PUB00088366]]. Archaeal and eukaryote RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis [[cite:PUB00007201]].</p> <p>Eukaryotic nuclear RNase P shares most of its protein components with another essential RNP enzyme, nucleolar RNase MRP [[cite:PUB00088366]]. RNase MRP (mitochondrial RNA processing) is an rRNA processing enzyme that cleaves various RNAs, including ribosomal, messenger, and mitochondrial RNAs. It can cleave a specific site within precursor rRNA to generate the mature 5'-end of 5.8S rRNA [[cite:PUB00042727]]. Despite its name, the vast majority of RNase MRP is localized in the nucleolus [[cite:PUB00088368]]. RNase MRP has been shown to cleave primers for mitochondrial DNA replication and CLB2 mRNA. In yeast, RNase MRP possesses one putatively catalytic RNA and at least 9 protein subunits (Pop1, Pop3-Pop8, Rpp1, Snm1 and Rmp1) [[cite:PUB00088367]]. Human RNase MRP complex consists of 267 nucleotides and supports the interaction with and among at least seven protein components: hPop1, hPop5, Rpp20, Rpp25, Rpp30, Rpp38, and Rpp40) and three additional proteins, hPop4, Rpp21 and Rpp14, have been reported to be associated with at least a subset of RNase MRP complexes [[cite:PUB00097414]].</p> <p>This entry represents the Pop5 from eukaryotes and related proteins from archaea.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ribonuclease P activity | Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. | ||
| Biological process | RNA metabolic process | The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable ribonuclease P/MRP protein subunit POP5-like [Glycine max] gi|356500813|ref|XP_003519225.1| | 7 | ||
| – | Ribonuclease P/MRP protein subunit POP5, putative; TAIR: AT1G04635.1 ribonuclease P family protein / Rpp14 family protein; Swiss-Prot: sp|Q6AWV1|POP5_ARATH Probable ribonuclease P/MRP protein subunit POP5; TrEMBL-Plants: tr|C6T5D2|C6T5D2_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0127900 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF160350 | SUPERFAMILY | 1 | 50.00 |