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IPR002759 is a RNase P subunit Pop5/Rpp14/Rnp2-like.
<p>This entry contains ribonuclease P (Rnp) proteins from eukaryotes and archaea. Rnp is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) [[cite:PUB00006321], [cite:PUB00100655]]. Archaeal and eukaryotic RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis [[cite:PUB00007201]].</p> <p>Human RNase P is composed of a singular protein Pop1 and three subcomplexes, the Rpp20-Rpp25 heterodimer, Pop5-Rpp14-(Rpp30)2-Rpp40 heteropentamer, and Rpp21-Rpp29-Rpp38 heterotrimer. Although both Pop5 and Rpp14 have similar protein structure, they share a very limited sequence similarity. Moreover, the C-terminal fragments after the conserved β sheets in Pop5 and Rpp14 exhibit distinct structural features that mediate interactions with Pop1 and Rpp40, respectively [[cite:PUB00007201]].</p> <p>In the hyperthermophilic archaeon Pyrococcus horikoshii OT3, RNase P is composed of the RNase P RNA (pRNA) and five proteins (PhoPop5, PhoRpp38, PhoRpp21, PhoRpp29, and PhoRpp30) [[cite:PUB00097410], [cite:PUB00097413]].</p> <p>Proteins in this entry include Rnp2 (also known as Pop5) from archaea and Pop5/Rpp14 from humans [[cite:PUB00007201]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ribonuclease activity | Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA. | ||
| Biological process | TRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable ribonuclease P/MRP protein subunit POP5-like [Glycine max] gi|356500813|ref|XP_003519225.1| | 7 | ||
| – | Ribonuclease P/MRP protein subunit POP5, putative; TAIR: AT1G04635.1 ribonuclease P family protein / Rpp14 family protein; Swiss-Prot: sp|Q6AWV1|POP5_ARATH Probable ribonuclease P/MRP protein subunit POP5; TrEMBL-Plants: tr|C6T5D2|C6T5D2_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0127900 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF160350 | SUPERFAMILY | 1 | 50.00 |